Male Fertility Before and After Androgen Abuse

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Josefine Windfeld-Mathiasen, Kim Peder Dalhoff, Jon Trærup Andersen, Marc Klemp, Anna Horwitz, Henrik Horwitz The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 2, February 2021, Pages 442–449, https://doi.org/10.1210/clinem/dgaa837 Published: 16 November 2020 Abstract Purpose Previous research has found that male users of androgens are diagnosed approximately twice as often with infertility. We therefore set out to investigate the fertility in men using androgens.Methods The study …

WellsRX TeamMale Fertility Before and After Androgen Abuse

Depicting SARS-CoV-2 faecal viral activity in association with gut microbiota composition in patients with COVID-19

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Tao Zuo, Qin Liu, Fen Zhang, Grace Chung-Yan Lui, Eugene YK Tso, Yun Kit Yeoh, Zigui Chen, Siaw Shi Boon, Francis KL Chan, Paul KS Chan, Siew C Ng Abstract Objective Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA was detected in faeces of patients with COVID-19, the activity and infectivity of the virus in the GI tract during disease …

WellsRX TeamDepicting SARS-CoV-2 faecal viral activity in association with gut microbiota composition in patients with COVID-19

Relation of body fat mass and fat-free mass to total mortality: results from 7 prospective cohort studies

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Anja M Sedlmeier, Sebastian E Baumeister, Andrea Weber, Beate Fischer, Barbara Thorand, Till Ittermann, Marcus Dörr, Stephan B Felix, Henry Völzke, Annette Peters… Show more The American Journal of Clinical Nutrition, https://doi.org/10.1093/ajcn/nqaa339 Published: 12 January 2021 ABSTRACT Background Fat mass and fat-free mass may play independent roles in mortality risk but available studies on body composition have yielded inconsistent results.Objective The aim was to determine the relations of body fat mass …

WellsRX TeamRelation of body fat mass and fat-free mass to total mortality: results from 7 prospective cohort studies

Insulin-like Growth Factor-1, Bone Mineral Density, and Fracture: A Mendelian Randomization Study

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Shuai Yuan, Zi-Hao Wan, Shi-Le Cheng, Karl Michaëlsson, Susanna C Larsson — The Journal of Clinical Endocrinology & Metabolism, dgaa963, https://doi.org/10.1210/clinem/dgaa963 Published: 19 January 2021 Abstract Context The associations of circulating insulin-like growth factor-1 (IGF-1) levels with bone mineral density and fracture risk are inconclusive in observational studies.Objective We conducted a mendelian randomization study to assess the associations of serum IGF-1 levels with estimated bone mineral …

WellsRX TeamInsulin-like Growth Factor-1, Bone Mineral Density, and Fracture: A Mendelian Randomization Study

Ultra-processed food consumption is associated with increased risk of all-cause and cardiovascular mortality in the Moli-sani Study

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Marialaura Bonaccio, Augusto Di Castelnuovo, Simona Costanzo, Amalia De Curtis, Mariarosaria Persichillo, Francesco Sofi, Chiara Cerletti, Maria Bendetta Donati, Giovanni de Gaetano, Licia Iacoviello on behalf of the Moli-sani Study InvestigatorsThe American Journal of Clinical Nutrition, nqaa299, https://doi.org/10.1093/ajcn/nqaa299 ABSTRACT Background Consumption of ultra-processed food (UPF) is gaining growing attention in relation to disease/mortality risk, but less is known on the main nutritional factors or biological mechanisms potentially underlying such associations.Objectives We aimed to assess …

WellsRX TeamUltra-processed food consumption is associated with increased risk of all-cause and cardiovascular mortality in the Moli-sani Study

No evidence for prolactin’s involvement in the post-ejaculatory refractory period

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Susana Valente, Tiago Marques, Susana Q Lima Abstract In many species, ejaculation is followed by a state of decreased sexual activity, the post-ejaculatory refractory period. Several lines of evidence have suggested prolactin, a pituitary hormone released around the time of ejaculation in humans and other animals, to be a decisive player in the establishment of the refractory period. However, data supporting this …

WellsRX TeamNo evidence for prolactin’s involvement in the post-ejaculatory refractory period

Early decline of androgen levels in healthy adult men: an effect of aging per se? A prospective cohort study

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Thiberiu Banica, Charlotte Verroken, Tim Reyns, Ahmed Mahmoud, Guy T’Sjoen, Tom Fiers, Jean-Marc Kaufman, Bruno LapauwThe Journal of Clinical Endocrinology & Metabolism, dgaa915, https://doi.org/10.1210/clinem/dgaa915 Abstract Context Androgen levels have been shown to decline in aging men. However, there is no consensus on the effect of aging, (changes in) BMI, lifestyle factors and intercurrent disease.Objective Investigating longitudinal changes in serum androgen levels in healthy men in relation to body …

WellsRX TeamEarly decline of androgen levels in healthy adult men: an effect of aging per se? A prospective cohort study

Vitamin D in human serum and adipose tissue after supplementation 

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Cora M Best, Devon V Riley, Thomas J Laha, Hannah Pflaum, Leila R Zelnick, Simon Hsu, Kenneth E Thummel, Karen E Foster-Schubert, Jessica N Kuzma, Gail Cromer… Show moreThe American Journal of Clinical Nutrition, Volume 113, Issue 1, January 2021, Pages 83–91, https://doi.org/10.1093/ajcn/nqaa295 Published: 12 November 2020 ABSTRACT Background Serum 25-hydroxyvitamin D [25(OH)D] concentration is an indicator of vitamin D exposure, but it is also influenced by clinical characteristics that affect 25(OH)D …

WellsRX TeamVitamin D in human serum and adipose tissue after supplementation 

Intermittent Fasting Improves Cardiometabolic Risk Factors and Alters Gut Microbiota in Metabolic Syndrome Patients

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Yi Guo, Shiyun Luo, Yongxin Ye, Songping Yin, Jiahua Fan, Min XiaThe Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 1, January 2021, Pages 64-79, https://doi.org/10.1210/clinem/dgaa644 Published: 06 October 2020 Abstract Context Intermittent fasting (IF) is an effective strategy to improve cardiometabolic health.Objective The objective of this work is to examine the effects of IF on cardiometabolic risk factors and the gut microbiota in patients with …

WellsRX TeamIntermittent Fasting Improves Cardiometabolic Risk Factors and Alters Gut Microbiota in Metabolic Syndrome Patients

Testosterone treatment to prevent or revert type 2 diabetes in men enrolled in a lifestyle programme (T4DM): a randomised, double-blind, placebo-controlled, 2-year, phase 3b trial

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Prof Gary Wittert, MD , Karen Bracken, PhD *, Kristy P Robledo, PhD *, Prof Mathis Grossmann, PhD *, Prof Bu B Yeap, PhD *, Prof David J Handelsman, MD * Published:January, 2021 DOI:https://doi.org/10.1016/S2213-8587(20)30367-3 Summary Background Men who are overweight or obese frequently have low serum testosterone concentrations, which are associated with increased risk of type 2 diabetes. We aimed to determine whether testosterone treatment prevents …

WellsRX TeamTestosterone treatment to prevent or revert type 2 diabetes in men enrolled in a lifestyle programme (T4DM): a randomised, double-blind, placebo-controlled, 2-year, phase 3b trial