Available Dosage Strengths
22 mg / 0.25 mg | 45 mg / 0.25 mg
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Clomiphene (Clomid®) Description1,2,3
Clomiphene was originally marketed under the brand name Clomid®. It is a fertility medication that induces ovulation in infrequently ovulating or anovulatory women. The drug that produces ovulation in patients with an intact hypothalamic-pituitary-ovarian axis and with ovaries that are capable of functioning normally. For women, clomiphene leads to the release of pituitary gonadotropins that initiates steroidogenesis and folliculogenesis, resulting in growth of the ovarian follicle and an increase in the circulating level of estradiol. For men, the drug increases testosterone through increased LH and FSH production who have low testosterone levels.
Anastrozole Description4
Anastrozole is a selective non-steroidal aromatase inhibitor. Anastrozole is used in postmenopausal women with hormone receptor-positive breast cancer.4
Clomiphene Mechanism of Action1,2,3
Clomiphene is classified as a selective-estrogen receptor-modulator due to its ability to compete with estradiol for estrogen receptors at the level of the hypothalamus. The drug blocks the normal negative feedback of circulating estradiol on the hypothalamus, preventing estrogen from lowering the output of gonadotropin releasing hormone. Gonadotropin releasing hormone pulses increases during clomiphene therapy and stimulates the pituitary gland to release more FSH and LH. For women, FSH and LH stimulate the ovaries to develop oocyte follicles. For men, it stimulates the production of testosterone.
Anastrozole Mechanism of Action 4,5,6
In postmenopausal women, estrogens are mainly derived from the action of the aromatase enzyme, which converts adrenal androgens (primarily androstenedione and testosterone) to estrone and estradiol. Suppression of estrogen biosynthesis in peripheral tissues and in cancer cells can be achieved by specifically inhibiting the aromatase enzyme. Therapeutically, this inhibition results in decreased systemic estrogen levels and increased systemic testosterone levels, which is therapeutic in estrogen-dependent breast cancers and in disease states where increased testosterone is important.
Clomiphene Adverse Reactions1,2
Anastrozole Adverse Reactions4
Common
Clomiphene Contraindications & Precautions1,2
Contraindications:
Precautions:
Anastrozole Contraindications & Precautions 4,6
Contraindications
Precautions:
Store tablets at controlled room temperature 59-86°F (15-30°C). Protect from heat, light, and excessive humidity, and store in closed containers.
This sheet is a summary. It may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.
