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What is Sermorelin?

First developed in the 1970’s, Sermorelin is a bioidentical synthetic hormone peptide sequence comprised of 29 amino acids, and is normally prescribed to be administered at night to maximize the body’s natural cycle of Human Growth Hormone (HGH) and stimulate the pituitary gland during REM sleep. Based on the literature, Sermorelin has been shown to be effective in raising growth hormone/insulin like-growth factor-1 levels which helps to:

  • Increase bone density and regenerate nerve tissue
  • Strengthen the cardiovascular system and immune system
  • Increase muscle mass and enhance energy levels
  • Improve ability to burn fat
  • Improve cognition and memory
  • Increase sex drive
  • Improve bone and mineral density
How Does Sermorelin Work?

Sermorelin essentially mimics the hypothalamic peptide, GHRH. Sermorelin acts directly on the pituitary gland, stimulating the somatotroph cells ability to produce and secrete GH. With the increase of serum GH, downstream effects occur. A notable hormone that is commonly used as a surrogate for growth hormone therapy, insulin like growth factor 1 (IGF-1), is known to increase with the administration of Sermorelin. IGF-I negatively regulates GHRH-mediated GH secretion.

Sermorelin is able to influence the concert of hormonal signaling that effects the GH axis. GH secretion from the anterior pituitary is regulated by GHRH, somatostatin, and GH secretagogues. The positive and negative opposing regulation of growth hormone by GHRH and somatostatin creates a rhythmic-circadian GH secretion. GH asked by signaling target cells, most notably increasing the synthesis of IGF-1 in the liver and peripheral tissues.

Sermorelin acts on the growth GHRHr in the pituitary to regulate cellular actives. GHRHr is the natural receptor for the endogenous hormone GHRH, a signaling hormone produced by the hypothalamus. This receptor among many other functions, controls growth hormone release, mainly by inhibition of somatostatin activity.

Sermorelin Dosage

Sermorelin dosages commonly range from 200mcg (0.2mg) to 1000mcg (1mg) daily. Generally, it is administered once daily before bed, or split into 2-3 smaller doses spread throughout the day. Both approaches can be effective, and have been shown to elicit positive results in clinical studies.

Sermorelin should be injected, and studies have confirmed that subcutaneous injections are the best delivery route. Generally, the injections are done in the stomach or thigh because individuals are able to pinch their skin and pull fatty tissue into a “roll,” where it can be injected. However, individuals may want to alternate the site of injections to avoid bruising and soreness. A four-day rotation may look like this:

  • ● Day 1 – Stomach
  • ● Day 2 – Thigh
  • ● Day 3 – Hip
  • ● Day 4 – Upper arm

Vials of Sermorelin should be stored refrigerated (2°-8°C/36°-46°F).

Sermorelin Benefits

There are many benefits to restoring your HGH levels. The decline in human growth hormone levels is associated with several aging symptoms such as lower energy levels, lower libido, decreased muscle mass/increased body fat, and a slower metabolism. While results may vary from patient to patient, clinical studies have shown that Sermorelin treatment can lead to a range of physical and mental benefits, including:

  • ● Increased lean body mass
  • ● Fat reduction
  • ● Improved energy
  • ● Increased vitality
  • ● Increased strength
  • ● Increased endurance
  • ● Accelerated wound healing
  • ● Improved cardiovascular and immune function
  • ● Better sleep quality
  • ● Improved bone density
  • ● Improved skin quality and higher collagen density
Sermorelin Side Effects

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

  • ● Facial flushing
  • ● Headache
  • ● Nausea
  • ● Pain
  • ● Redness or swelling at injection site
  • ● Paleness
  • ● Strange taste in mouth
  • ● Vomiting

If any of these SEVERE side effects occur, seek medical attention right away:

Severe allergic reactions, including:

    • ● Rash
    • ● Hives
    • ● Itching
    • ● Difficulty breathing
    • ● Tightness in chest
    • ● Swelling of mouth, face, lips, or tongue

These are not ALL the possible side effects of Sermorelin. For more information, be sure to ask your doctor or pharmacist.


Sermorelin therapy should be carried out under the regular guidance of a physician who is experienced in the diagnosis and management of growth hormone deficiencies.

Breast-feeding Women: It is unknown if Sermorelin acetate is excreted in breast milk. If you are or will be breast-feeding while using Sermorelin acetate, check with your doctor or pharmacist to discuss the risks to your baby.

How do you use Sermorelin?​
  • Sermorelin is usually administered as an injection at your doctor’s office. If you are using Sermorelin at home, carefully follow the injection procedures taught to you by your health care provider.
  • If your Sermorelin contains particles or is discolored, or if the vial is cracked or damaged in ANY way, DO NOT use it!
  • Do not shake Sermorelin when mixing!
  • Use Sermorelin immediately after mixing. Discard any unused medicine.
  • All other growth hormone therapy should be stopped 1 week before using Sermorelin. Contact your doctor or pharmacist if you have questions.
  • Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use.
  • If you miss a dose of Sermorelin, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. DO NOT use 2 doses at once.
How long does Sermorelin take to work?

While patients will notice some significant increases in changes in the body after the first month, the full benefits are usually fully noticed after 3-6 months of therapy. Once injected,  Sermorelin is eliminated from then body very quickly and therefore needs to be injected frequently. Its actions are dependent on a chain reaction of biological processes which result in elevated and sustained HGH and growth factors. It takes some time for levels to become optimal and initiate the benefits we are seeking to achieve. This timeline is common for many patients:

● Month 1

  •     – Increased energy
  •     – Improved stamina
  •     – Deeper, more restful sleep

● Month 2

  •     – Improved skin, reduced wrinkles
  •     – Stronger nails and hair
  •     – Increased metabolism

● Month 3

  •     – Enhanced sex drive and performance
  •     – Improved mental focus
  •     – Improved joint health

● Month 4

  •     – Continued weight reduction
  •     – Improved skin elasticity
  •     – Increased lean muscle mass

● Month 5

  •     – Noticeably fuller and healthier hair
  •     – Reduced appearance of wrinkles, better skin tone
  •     – Continued reduction in belly fat

● Month 6

    •     – 5-10% reduction in body fat (without exercise/diet)
    •     – 10% increase in lean muscle mass
    •     – Improved vitality due to organ regrowth
How often should I take Sermorelin?

A dosage of 0.2-0.3 mcg once daily at bedtime by subcutaneous injection is recommended.

Does Sermorelin need to be refrigerated?

Yes. Vials of  Sermorelin should be stored refrigerated (2°-8°C/36°-46°F).

What are the differences between Sermorelin therapy and HGH therapy?

HGH Therapy involves the direct injection of HGH into the body and this increases HGH levels by adding HGH to the internal HGH that your body creates on it’s own. Sermorelin on the other hand increases HGH through stimulating your body to produce more HGH on it’s own. Both therapies achieve the same goal, which is the increase in HGH levels, but through different mechanisms.

Another major difference between Sermorelin therapy and HGH therapy is the price. Sermorelin acetate has been around for a long time, has been the subject of a great deal of research, and costs FAR less than many other GHRH analogues. A month of Sermorelin therapy, on the average, costs $200-300. HGH therapy on the other hand, will cost $1500-2000 per month.

What are the differences between Sermorelin and Ipamorelin?

Although both Sermorelin and Ipamorelin stimulate HGH in the body, Sermorelin acts differently, it that it works to increase the body’s production of HGH NATURALLY.

Ipamorelin is synthetic. Because Sermorelin is natural, there’s no fear of the loss of natural HGH production or worry for the rick of excessive dosage.

Patients with questions about an order, prescription, or medication, please call (866) 506-2174 and ask to speak to a pharmacist.

Contact Numbers

Main Phone: (866) 506-2174

Prescription Fax Line: (352) 401-5650

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