Testosterone Propionate Injection

Available Dosage Strengths

100 mg/mL

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Product Overview

Description

Testosterone Propionate Injection Description^1-4

Testosterone Propionate Injection is a compounded injectable testosterone ester medication consisting of testosterone propionate. It has been used in testosterone replacement therapy to treat male hypogonadism.  Testosterone propionate has a half-life of approximately 4.5 days.^3,4 Testosterone that has not been esterified has a half-life of as short as 10 minutes. Thus, the esterification process provides for a longer duration of effect for the testosterone.

Mechanism of Action

Mechanism of Action^1-4

The esterification of testosterone propionate occurs on the 17b carbon of the testosterone structure. The testosterone propionate ester extends the duration of action and is useful for less frequent, intramuscular, or subcutaneous injections.  Once administered, the testosterone propionate ester is cleaved, releasing free testosterone into the bloodstream. Testosterone then binds to androgen receptors in various tissues, exerting anabolic and androgenic effects. Testosterone has a role in influencing the development and maintenance of male secondary sexual characteristics, stimulation of muscle and bone growth, and regulation of libido and mood.

Adverse Reactions

Common¹

Acne
Hypertension
Injection site pain or inflammation
Mood swings or irritability
Increased or decreased libido
Gynecomastia

Contraindications & Precautions

Contraindications¹  

Known hypersensitivity or intolerance to testosterone or either ester component
Males with carcinoma of the breast or known or suspected carcinoma of the prostate
Pregnant or breastfeeding women
Patients with serious cardiac, hepatic, or renal disease

Precautions¹  

Monitor hematocrit and hemoglobin levels.
Regularly assess liver function tests.
Evaluate lipid profiles periodically.
Monitor for signs of sleep apnea.
Use cautiously in patients with a history of cardiovascular disease.

Storage

Store at 20°C to 25°C (68°F to 77°F) in a dry place, away from heat and light. DO NOT REFRIGERATE. Do not freeze. Keep out of reach of children.

References

Clinical Pharmacology Testosterone clinical monograph accessed September 1 2025 ; https://www.clinicalkey.com/pharmacology/monograph/595?n=Testosterone 
Pubchem testosterone propionate. https://pubchem.ncbi.nlm.nih.gov/compound/Testosterone-Propionate Accessed September 1, 2025
Testosterone Propionate – Steroids Profile – Steroidal.com. https://www.steroidal.com/steroid-profiles/testosterone-propionate/ June 5, 2019 Accessed September 1, 2025
Testosterone propionate: Uses, Interactions, Mechanism of Action | DrugBank Online. https://go.drugbank.com/drugs/DB01420. Accessed September 1, 2025.

Disclaimer

This information is for educational purposes only. This compounded product has not been reviewed, approved, or evaluated by the Food and Drug Administration for safety and effectiveness. This product is not intended to diagnose, treat, cure, or prevent any disease. No claims are made regarding treatment, cure, or prevention of any disease or condition.

This information may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.