Sermorelin Rapid Dissolve Mini-Tabs

Available Dosage Strengths

400 mcg

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Product Overview

Description

Sermorelin Rapid Dissolving MiniTab Description^1-6

Sermorelin is a synthetic peptide analog of endogenous growth hormone releasing hormone (GHRH), consisting of the first 29 amino acids of the 44-residue natural human GHRH. It is used as a diagnostic agent and as a growth hormone secretagogue to stimulate endogenous production of human growth hormone (hGH) by the pituitary gland.

Mechanism of Action

Mechanism of Action^1-6

Sermorelin acts as an agonist at the GHRH receptor in the anterior pituitary, stimulating somatotroph cells to increase the synthesis and pulsatile release of endogenous growth hormone (GH). This in turn stimulates the liver to produce insulin-like growth factor-1 (IGF-1), which mediates many of the anabolic and metabolic effects associated with human growth hormone.

Unlike exogenous recombinant human growth hormone (rhGH), sermorelin stimulates physiologic GH production while preserving feedback regulation via somatostatin and IGF-1 pathways. This supports a more natural circadian rhythm of GH release.

Adverse Reactions

Common

Injection site reactions (pain, redness, swelling)
Facial flushing
Headache
Nausea
Dizziness
Sleep disturbances (insomnia or drowsiness)

Contraindications & Precautions

Contraindications & Precautions^1-6

Contraindications:

Hypersensitivity to sermorelin or any component of the formulation
Active malignancies, particularly those influenced by GH or IGF-1
Intracranial lesion
Use during pregnancy and breastfeeding (due to insufficient safety data)

Precautions:

Use with caution in patients with a history of cancer or intracranial lesions
May unmask latent diabetes mellitus due to its GH-stimulating properties

Storage

Store at 20°C to 25°C (68°F to 77°F). Protect from light, moisture, and heat.

References

Walker RF. Sermorelin: a better approach to management of adult-onset growth hormone insufficiency? Clin Interv Aging. 2006;1(4):307-8. doi: 10.2147/ciia.2006.1.4.307. PMID: 18046908; PMCID: PMC2699646.
RxList. Sermorelin Acetate Injection. https://www.rxlist.com/sermorelin-acetate-drug.htm
Bianco AC, et al. “Physiology of the GHRH–GH–IGF1 axis.” Endocr Rev. 2002;23(1):38–89.
Drugs.com. Sermorelin Acetate; accesses June 27 2025; https://www.drugs.com/cdi/sermorelin-acetate.html
Walker RF. “Clinical utility of growth hormone-releasing peptides.” Drugs. 1994;47(2):269-273. PubMed PMID: 7517376
Geref Description Archive.(discontinued product); accessed June 26 2025; https://worldhealth.net/news/geref_seristim/

Disclaimer

This sheet is a summary. It may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.