Ondansetron Tablets

(Commercial Product)

Available Dosage Strengths

4 mg  |  8 mg

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Disclaimer: Images are for reference only; actual products may vary.

Product Overview

Ondansetron Tablets Description1,2

Ondansetron, a 5-HT₃ receptor antagonist, that is used clinically as an antiemetic. It prevents and treats nausea and vomiting specifically for patients on chemotherapy, receiving radiation or after surgery or after a medical procedure.

References

  1. FDA Label – Ondansetron HCL. https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/020103s035_020605s019_020781s019lbl.pdf Revised October 2016 Accessed May 22, 2025.
  2. Clinical Pharmacology ondansetron clinical monograph 2025 https://www.clinicalkey.com/pharmacology/

Mechanism of Action1,2

Serotonin (5-HT₃) receptors are found in the gastrointestinal tract and centrally in the chemoreceptor trigger zone (CTZ) in the brain. Ondansetron prevents serotonin from binding to serotonin receptors in the gastrointestinal tract and the chemoreceptor trigger zone. By preventing serotonin from binding to these receptors, it inhibits vomiting reflexes, specifically when chemotherapy, radiation, and anesthesia is administered.

Common1,2

  • Headache
  • Constipation
  • Fatigue
  • Dizziness

Contraindications1,2

  • Known hypersensitivity to ondansetron or other 5-HT₃ antagonists.

Precautions1,2

  • QT interval prolongation: avoid in patients with risk factors for QT prolongation including congenital long QT syndrome or electrolyte imbalances. (hypokalemia, hypomagnesemia)—QT interval prolongation can lead to torsades de pointes.
  • Hepatic impairment: In severe hepatic dysfunction, do not exceed 8 mg total daily dose.
  • Store at controlled room temperature (20°C to 25°C / 68°F to 77°F)
  • Protect from moisture and light
  • Keep in a tightly closed container
  1. FDA Label – Ondansetron HCL. https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/020103s035_020605s019_020781s019lbl.pdf Revised October 2016 Accessed May 22, 2025.
  2. Clinical Pharmacology ondansetron clinical monograph 2025 https://www.clinicalkey.com/pharmacology/

This information is for educational purposes only.

Wells Pharmacy Network distributes certain FDA-approved commercial products that are manufactured by third-party pharmaceutical companies. These products are not compounded or manufactured by Wells Pharmacy Network. Product availability at the time of dispensing may vary due to supply chain conditions.

This information is a summary. It may not cover all possible drug information about this product. For complete product information, refer to the manufacturer’s prescribing information and labeling. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088.  A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.

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