Progesterone Capsules IR

(Commercial Product)

Available Dosage Strengths

100 mg  |  200 mg

Want to Prescribe?

Disclaimer: Images are for reference only; actual products may vary.

Product Overview

Progesterone Capsules IR Description1-3

Micronized progesterone is a bioidentical form of the naturally occurring hormone progesterone, formulated into micron-sized particles to enhance oral absorption. It is used in various clinical settings within women’s health, including hormone replacement therapy (HRT), management of luteal phase defects, menstrual disorders, infertility treatments, and prevention of endometrial hyperplasia in postmenopausal women receiving estrogen therapy. Progesterone can be prepared in capsule form to be taken by mouth.

References

  1. FDA Label for Prometrium® (micronized progesterone); accessed July 2025 through: https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/019781s013lbl.pdf
  2. Cynthia A. Stuenkel, Susan R. Davis, Anne Gompel, Mary Ann Lumsden, M. Hassan Murad, JoAnn V. Pinkerton, Richard J. Santen, Treatment of Symptoms of the Menopause: An Endocrine Society Clinical Practice Guideline, The Journal of Clinical Endocrinology & Metabolism, Volume 100, Issue 11, 1 November 2015, Pages 3975–4011, accessed July 2025 through: https://doi.org/10.1210/jc.2015-2236
  3. Clinical Pharmacology Progesterone clinical monograph accessed July 2025 through: https://www.clinicalkey.com/pharmacology/monograph/515?n=Progesterone

Mechanism of Action 1-3

Progesterone is a steroid hormone primarily secreted by the corpus luteum and, during pregnancy, the placenta, it binds PR-A & PR-B receptors and the primary actions in women include:

  • Endometrial transformation: Converts the endometrium from a proliferative to a secretory state, supporting implantation and pregnancy.
  • Regulation of gonadotropin secretion: Via negative feedback on the hypothalamic-pituitary axis.
  • Stabilization of the endometrium helps to prevent irregular bleeding in women receiving estrogen therapy.
  • CNS effects: Modulates mood, sleep, and neuroprotective pathways through GABA-A receptor modulation.

Common1-3

  • Drowsiness or sedation
  • Breast tenderness
  • Headache
  • Bloating
  • Mood changes
  • Irregular bleeding or spotting
  • Dizziness

Contraindications1-3

Micronized progesterone should not be used in individuals with:

  • Known or suspected pregnancy (when used outside pregnancy-supporting protocols)
  • Undiagnosed abnormal menstrual bleeding
  • Known, suspected, or history of breast cancer
  • Active or history of thromboembolic disorders (stroke, DVT, heart attack etc…)
  • Liver dysfunction or disease
  • Hypersensitivity to progesterone or any formulation components

Precautions1-3

  • Use in patients with a history of depression should be monitored closely.
  • Caution in cardiovascular disease, migraine, or seizure disorders.
  • In women with a uterus, progesterone is required alongside estrogen to prevent endometrial hyperplasia.
  • Store at controlled room temperature (20°C to 25°C / 68°F to 77°F)
  • Protect from moisture and light
  • Keep in a tightly closed container
  1. FDA Label for Prometrium® (micronized progesterone); accessed July 2025 through: https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/019781s013lbl.pdf
  2. Cynthia A. Stuenkel, Susan R. Davis, Anne Gompel, Mary Ann Lumsden, M. Hassan Murad, JoAnn V. Pinkerton, Richard J. Santen, Treatment of Symptoms of the Menopause: An Endocrine Society Clinical Practice Guideline, The Journal of Clinical Endocrinology & Metabolism, Volume 100, Issue 11, 1 November 2015, Pages 3975–4011, accessed July 2025 through: https://doi.org/10.1210/jc.2015-2236
  3. Clinical Pharmacology Progesterone clinical monograph accessed July 2025 through: https://www.clinicalkey.com/pharmacology/monograph/515?n=Progesterone

This information is for educational purposes only.

Wells Pharmacy Network distributes certain FDA-approved commercial products that are manufactured by third-party pharmaceutical companies. These products are not compounded or manufactured by Wells Pharmacy Network. Product availability at the time of dispensing may vary due to supply chain conditions.

This information is a summary. It may not cover all possible drug information about this product. For complete product information, refer to the manufacturer’s prescribing information and labeling. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088.  A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.

EXPLORE MORE

Featured Medications

We deliver your orders fast and with complete discretion, straight to your door.

We're licensed to ship nationwide

Our mission is to elevate compounding industry standards through a unique combination of superior science and service.

Ready to get started?