Clomid™ – Tablets

Available Dosage Strengths

50 mg

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Disclaimer: Images are for reference only; actual products may vary.

Product Overview

Description

Clomiphene (Clomid™) Description^1,2

Clomiphene was originally marketed under the brand name Clomid™. It is a fertility medication that induces ovulation in infrequently ovulating or anovulatory women. The drug produces ovulation in patients with an intact hypothalamic-pituitary-ovarian axis and with ovaries that are capable of functioning normally. For women, clomiphene can lead to the release of pituitary gonadotropins that initiates steroidogenesis and folliculogenesis, resulting in growth of the ovarian follicle and an increase in the circulating level of estradiol. For men who have low testosterone, the drug increases testosterone through increased LH and FSH production.

References

Clomiphene citrate package insert Clomid Revised October 2012 Accessed June 2, 2025. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/016131s026lbl.pdf
Clinical Pharmacology clomiphene clinical monograph 2025 https://www.clinicalkey.com/pharmacology/

Mechanism of Action

Mechanism of Action^1,2,3

Clomiphene is classified as a selective-estrogen receptor-modulator due to its ability to compete with estradiol for estrogen receptors at the level of the hypothalamus. The drug blocks the normal negative feedback of circulating estradiol on the hypothalamus, preventing estrogen from lowering the output of gonadotropin releasing hormone. Gonadotropin releasing hormone pulses increases during clomiphene therapy and stimulates the pituitary gland to release more FSH and LH. For women, FSH and LH stimulate the ovaries to develop oocyte follicles. For men, it can stimulate the production of testosterone.

Adverse Reactions

Adverse Reactions²

Hot flashes
Abdominal or pelvic discomfort
Breast tenderness
Nausea, vomiting
Mood swings, headaches

Contraindications & Precautions

Contraindications & Precautions^1,2

Contraindications:

Contraindicated during pregnancy
Liver disease or history of hepatic dysfunction
Abnormal uterine bleeding of unknown cause
Ovarian cysts unrelated to polycystic ovary syndrome
Uncontrolled thyroid or adrenal dysfunction
Pituitary or hypothalamic tumors

Precautions:

Visual symptoms (blurring, scotomas) may occur; discontinue if persistent
Increased risk of multiple births (twins, triplets)
Spontaneous abortion and congenital anomalies

Storage

Store at controlled room temperature (20°C to 25°C / 68°F to 77°F)
Protect from moisture and light
Keep in a tightly closed container

References

Clomiphene citrate package insert Clomid Revised October 2012 Accessed June 2, 2025. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/016131s026lbl.pdf
Clinical Pharmacology clomiphene clinical monograph 2025 https://www.clinicalkey.com/pharmacology/
Karen M. Wheeler, Devang Sharma, Parviz K. Kavoussi, Ryan P. Smith, Raymond Costabile, Clomiphene Citrate for the Treatment of Hypogonadism, Sexual Medicine Reviews, Volume 7, Issue 2, April 2019, Pages 272–276.

Disclaimer

This information is for educational purposes only.

Wells Pharmacy Network distributes certain FDA-approved commercial products that are manufactured by third-party pharmaceutical companies. These products are not compounded or manufactured by Wells Pharmacy Network. Product availability at the time of dispensing may vary due to supply chain conditions.

This information is a summary. It may not cover all possible drug information about this product. For complete product information, refer to the manufacturer’s prescribing information and labeling. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.