Depo® Testosterone Cypionate Injection, USP

(Commercial Product)

Available Dosage Strengths

200 mg/mL

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Product Overview

Tesosterone Cypionate Injection is a compounded injectable product used for testosterone replacement when there is a decline in testosterone levels as seen with hypogonadism and to support energy, mood and sexual health.

Testosterone cypionate is a long-acting testosterone ester. It has a half-life of 8 days.3,4 Testosterone that has not been esterified has a half-life of as short as 10 minutes. Thus, the esterification process increases the half-life dramatically. 1-4

Testosterone Cypionate is an esterified form of testosterone. The ester extends the duration of action and is useful for less frequent, intramuscular, or subcutaneous injections. Once administered, the ester is cleaved, releasing free testosterone into the bloodstream. Testosterone then binds to androgen receptors in various tissues, exerting anabolic and androgenic effects. These effects may include the development and maintenance of male secondary sexual characteristics, stimulation of muscle and bone growth, and regulation of libido and mood.1-4

Common1-4

  • Acne
  • Hypertension
  • Gastrointestinal (nausea, vomiting, abdominal pain)
  • Headache
  • Weight gain
  • Insomnia
  • Injection site pain or inflammation
  • Mood swings or irritability
  • Increased or decreased libido
  • Gynecomastia

Contraindications:1-4

  • Known hypersensitivity to testosterone, cypionate or any component of the formulation
  • Known hypersensitivity to cotton seed oil
  • Males with carcinoma of the breast or known or suspected carcinoma of the prostate
  • Pregnant or breastfeeding women
  • Patients with serious cardiac, hepatic, or renal disease

Precautions:

  • Monitor hematocrit and hemoglobin levels.
  • Regularly assess liver function tests.
  • Evaluate lipid profiles periodically.
  • Monitor for signs of sleep apnea.
  • Use cautiously in patients with a history of cardiovascular disease.

Store at 20°C to 25°C (68°F to 77°F) in a dry place, away from heat and light. DO NOT REFRIGERATE. Do not freeze. Keep out of reach of children and pets.4

  1. Clinical Pharmacology Testosterone clinical monograph accessed May 8 2025 ; https://www.clinicalkey.com/pharmacology/monograph/595?n=Testosterone
  2. https://go.drugbank.com/drugs/DB13944
  3. Mayo Clinic. Testosterone cypionate (intramuscular route). https://www.mayoclinic.org/drugs-supplements/testosterone-cypionate-intramuscular-route/description/drg-20563731
  4. Depo Testosterone(Testosterone Cypionate) [package insert] Pfizer Inc NY, NY 10017, revised July 2018, accessed May 2025 through: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/085635s040lbl.pdf

This information is for educational purposes only. This compounded product has not been reviewed, approved, or evaluated by the Food and Drug Administration for safety and effectiveness. This product is not intended to diagnose, treat, cure, or prevent any disease. No claims are made regarding treatment, cure, or prevention of any disease or condition.

This information may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088.  A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.

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