Bremelanotide (PT-141) Nasal Spray

Available Dosage Strengths

10 mg/mL

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Product Overview

Description

Bremelanotide is a melanocortin receptor (MCR) agonist. It is indicated for the treatment of premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD) as characterized by low sexual desire that causes marked distress or interpersonal difficulty and is NOT due to:

A co-existing medical or psychiatric condition.
Problems with the relationship, or the effects of medication or drug substance. [1,2]

Mechanism of Action

Bremelanotide, a MCR agonist, non-selectively works on several receptor subtypes MC1R-MC5R in the central nervous system. MC1R and MC4R are thought to be the most relevant. MC4R are commonly present in the central nervous system. Although the mechanism of action is not fully elucidated, the drug is thought to activate pathways in the brain that are involved in sexual responses. [1,2]

Adverse Reactions

Gastrointestinal including nausea and vomiting
Increased blood pressure
Hyperpigmentation [1,2]

Contraindications & Precautions

Contraindications:

Known hypersensitivity to bremelanotide or any component of the formulation.
Patients with uncontrolled hypertension and cardiovascular disease.
Pregnancy not recommended when taking bremelanotide.

Precautions:

Use caution in patients with renal or hepatic impairment. [1,2]

Storage

Store at or below 25°C (77°F). Do not freeze. Protect from light. [1]

References

Bremelanotide package insert. Revised June 2019. Accessed June 3, 2025. www.accessdata.fda.gov/drugsatfda_docs/label/2019/210557s000lbl.pdf
Clinical Pharmacology bremelanotide clinical monograph 2025 https://www.clinicalkey.com/pharmacology/

Disclaimer

This sheet is a summary. It may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.