Anastrozole Tablets

(Commercial Product)

Available Dosage Strengths

1 mg

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Disclaimer: Images are for reference only; actual products may vary.

Product Overview

Description

Anastrozole Tablets Description¹

Anastrozole is a oral tablet that delivers the aromatase inhibitor anastrozole. This compounded formulation allows for absorption through the oral mucosa, offering improved bioavailability and convenience compared to traditional oral tablets, especially for patients with difficulty swallowing or those seeking faster onset of action. Anastrozole is used in postmenopausal women with hormone receptor-positive breast cancer.

References

Clinical Pharmacology anastrozole clinical monograph 2025 https://www.clinicalkey.com/pharmacology/
de Ronde W, de Jong FH. Aromatase inhibitors in men: effects and therapeutic options. Reprod Biol Endocrinol. 2011 Jun 21;9:93.
Anastrozole (Ascend Laboratories, LLC): FDA Package Insert. https://medlibrary.org/lib/rx/meds/anstrozole-15/. Anastrozole package insert. Revised 03/11 Accessed May 20, 2025.

Mechanism of Action

Mechanism of Action^1-2

Anastrozole is a selective non-steroidal aromatase inhibitor. In postmenopausal women, estrogens are mainly derived from the action of the aromatase enzyme, which converts adrenal androgens (primarily androstenedione and testosterone) to estrone and estradiol. Suppression of estrogen biosynthesis in peripheral tissues and in cancer cells can be achieved by specifically inhibiting the aromatase enzyme. Therapeutically, this inhibition results in decreased systemic estrogen levels and increased systemic testosterone levels, which is therapeutic in estrogen-dependent breast cancers and in disease states where increased testosterone is important.

Adverse Reactions

Common¹

Hot flashes
Gastrointestinal (nausea, vomiting, abdominal pain)
Headache
Weight gain
Osteopenia
Insomnia

Contraindications & Precautions

Contraindications^1-3

Known hypersensitivity to anastrozole or any component of the formulation.

Precautions^1-3

Use with caution in patients with pre-existing hypercholesterolemia.
Use with caution in patients with pre-existing osteoporosis; consider bone mineral density (BMD) monitoring in patients treated with anastrozole.
Not recommended in patients who are pregnant.
Use with caution in patients with pre-existing ischemic cardiac disease.

Storage

Store at controlled room temperature (20°C to 25°C / 68°F to 77°F)
Protect from moisture and light
Keep in a tightly closed container

References

Clinical Pharmacology anastrozole clinical monograph 2025 https://www.clinicalkey.com/pharmacology/
de Ronde W, de Jong FH. Aromatase inhibitors in men: effects and therapeutic options. Reprod Biol Endocrinol. 2011 Jun 21;9:93.
Anastrozole (Ascend Laboratories, LLC): FDA Package Insert. https://medlibrary.org/lib/rx/meds/anstrozole-15/. Anastrozole package insert. Revised 03/11 Accessed May 20, 2025.

Disclaimer

This information is for educational purposes only.

Wells Pharmacy Network distributes certain FDA-approved commercial products that are manufactured by third-party pharmaceutical companies. These products are not compounded or manufactured by Wells Pharmacy Network. Product availability at the time of dispensing may vary due to supply chain conditions.

This information is a summary. It may not cover all possible drug information about this product. For complete product information, refer to the manufacturer’s prescribing information and labeling. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.