Tretinoin / CoQ10

Available Dosage Strengths

0.025% / 1%

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Product Overview

Description

Tretinoin^1,2

Tretinoin, a naturally occurring derivative of vitamin A, is also called all-trans-retinoic acid. Retinoids may facilitate regulation of cell reproduction, cell proliferation and differentiation. Tretinoin is thought to facilitate skin cell turnover to improve skin texture and tone. It is used for the treatment of acne vulgaris and for photoaging including facial wrinkles, skin roughness and hyperpigmentation. For hyperpigmentation disorders, tretinoin may prevent the transcription of the enzyme tyrosinase which minimizes melanogenesis.

Coenzyme Q10 (CoQ10)^3-5

Coenzyme Q10 (CoQ10), a lipophilic molecule found in the body has a primary role in cellular energy metabolism through the mitochondrial electron transport chain. It also functions as an antioxidant to decrease free radicals. This neutralization of free radicals and activity in the mitochondrial transport chain system can help to decrease signs of skin aging and can help regenerate skin elasticity involved in skin aging. The level of CoQ10 decreases as you age providing less protective effects to radical oxygen species.

The combination of tretinoin and CoQ10 facilitate skin turnover and increases the protective antioxidant effects that improves skin integrity.

Mechanism of Action

Tretinoin^1,2

Tretinoin binds to retinoic acid receptors (RARs) alpha, beta, and gamma along with retinoid X receptors (RXRs) to block inflammatory mediators. In addition, during the binding to the retinoid acid receptor, the production of procollagen increases to augment collagen type I and III formations.

CoQ10 ^3-5

CoQ10 has a critical role as a cofactor for mitochondrial enzyme pathways within cells. Impairments in mitochondrial function disrupt cellular adenosine triphosphate (ATP) production and thereby inhibit the fuel for cellular repair mechanisms and function. Reactive oxygen species accumulate, which in turn can damage mitochondria, cellular membranes, and mitochondrial DNA, accelerating skin aging in a negative feedback loop. Coenzyme Q helps to facilitate mitochondrial activity and maintain energy. CoQ10 inhibits the ability of free radicals to activate mitogen activated protein kinase pathway and the ability of collagenases to form minimizing damage to collagen. It also decreases damage caused by lipid peroxidases to li[pids, proteins and DNA.

Adverse Reactions

Tretinoin:^1,2

Common

Burning sensation, irritation, erythema
Do not use in patients with open wounds
Photosensitivity with tretinoin
Initial “retinoid reaction” is common and usually subsides with continued use.

CoQ10:^3-5

Generally well-tolerated in topical formulations.
No major adverse effects reported in clinical studies

Contraindications & Precautions

Contraindications:^1,2

Hypersensitivity or intolerance to tretinoin or CoQ10
Presence of active dermatitis, eczema, or open wounds at the application site
Avoid use in pregnant patients

Precautions:^1,2

Use with other agents that can dry or irritate the skin (benzoyl peroxide)

Storage

Store at controlled room temperature (20–25°C / 68–77°F) [3]. Protect from excessive heat and direct sunlight. Keep the container tightly closed. Do not freeze. Keep out of reach of children.

References

Clinical Pharmacology tretinoin clinical monograph 2025 https://www.clinicalkey.com/pharmacology/
Yoham AL, Casadesus D. Tretinoin. March 27, 2023. Accessed July 27, 2025.
Lain ET, Agrawal N, Ruvolo E, Weise JM, Callender VD. The Role of Coenzyme Q10 in Skin Aging and Opportunities for Topical Intervention: A Review. J Clin Aesthet Dermatol. 2024 Aug;17(8):50-55.
Knott A, Achterberg V, Smuda C, et al. Topical treatment with coenzyme Q10-containing formulas improves skin’s Q10 level and provides antioxidative effects. Biofactors. 2015 Nov-Dec;41(6):383-90.
Vasilescu A. The Full 101 On Coenzyme Q10 In Skincare: The Energy-Boosting Nutrient for Healthy Skin. Women’s Concepts. March 21, 2023. Accessed July 31, 2025.

Disclaimer

This sheet is a summary. It may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.