Ondansetron Tablets

(Commercial Product)

Available Dosage Strengths

4 mg | 8 mg

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Disclaimer: Images are for reference only; actual products may vary.

Product Overview

Description

Ondansetron Tablets Description^1,2

Ondansetron, a 5-HT₃ receptor antagonist, that is used clinically as an antiemetic. It prevents and treats nausea and vomiting specifically for patients on chemotherapy, receiving radiation or after surgery or after a medical procedure.

Mechanism of Action

Mechanism of Action^1,2

Serotonin (5-HT₃) receptors are found in the gastrointestinal tract and centrally in the chemoreceptor trigger zone (CTZ) in the brain. Ondansetron prevents serotonin from binding to serotonin receptors in the gastrointestinal tract and the chemoreceptor trigger zone. By preventing serotonin from binding to these receptors, it inhibits vomiting reflexes, specifically when chemotherapy, radiation, and anesthesia is administered.

Adverse Reactions

Common^1,2

Headache
Constipation
Fatigue
Dizziness

Contraindications & Precautions

Contraindications^1,2

Known hypersensitivity to ondansetron or other 5-HT₃ antagonists.

Precautions^1,2

QT interval prolongation: avoid in patients with risk factors for QT prolongation including congenital long QT syndrome or electrolyte imbalances. (hypokalemia, hypomagnesemia)—QT interval prolongation can lead to torsades de pointes.
Hepatic impairment: In severe hepatic dysfunction, do not exceed 8 mg total daily dose.

Storage

Store at controlled room temperature (20°C to 25°C / 68°F to 77°F)
Protect from moisture and light
Keep in a tightly closed container

References

FDA Label – Ondansetron HCL. https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/020103s035_020605s019_020781s019lbl.pdf Revised October 2016 Accessed May 22, 2025.
Clinical Pharmacology ondansetron clinical monograph 2025 https://www.clinicalkey.com/pharmacology/

Disclaimer

Wells Pharmacy Network distributes certain FDA-approved commercial products that are manufactured by third-party pharmaceutical companies. These products are not compounded or manufactured by Wells Pharmacy Network. Product availability at the time of dispensing may vary due to supply chain conditions.

This information is for educational purposes only. Compounded products have not been reviewed, approved, or evaluated by the FDA for safety and effectiveness. It is not intended to diagnose, treat, cure, or prevent any disease. No claims are made regarding treatment, cure, or prevention of any disease or condition.

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