Phentermine / 7-Keto DHEA / Calcium Pyruvate SR K100 Capsules

Available Dosage Strengths

15 mg / 10 mg / 100 mg | 30 mg / 10 mg / 100 mg | 37.5 mg / 10 mg / 100 mg

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Product Overview

Description

Phentermine^1-4

Phentermine, a stimulant of the sympathetic central nervous system, is used as an anorectic. It is a schedule IV-controlled substance. The drug closely mimics amphetamine in activity and structure. The drug is also an analog of methamphetamine. Phentermine can be used itself or combined in lower doses with other drugs to enhance its effect. The drug has been approved since 1959 and is used for the following indications:

For the treatment of obesity (short term use in combination with reduced calorie intake and lifestyle modifications) in patients with a body mass index of 30 kg/m2 or patients with a body mass index of 27 kg/m2 with a comorbidity of hypertension, diabetes or dyslpidemia.

7-Keto DHEA^5-8

7-Keto-DHEA is a naturally occurring metabolite of dehydroepiandrosterone (DHEA). Unlike DHEA, it cannot be converted into sex hormones such as testosterone or estradiol. There is some evidence of effectiveness in the following areas: weight loss, metabolic support, improved immune function, and cognitive enhancement.

Calcium Pyruvate^9-12

Calcium pyruvate is formed during carbohydrate metabolism (when glucose is turned into energy). It is the calcium salt of pyruvic acid. Calcium pyruvate has been studied for anti-inflammatory effects, cardioprotective effects, and as an aid to facilitate weight loss.

Mechanism of Action

Phentermine^1,2

Phentermine predominantly acts in the central nervous system (CNS), within the hypothalamus and limbic systems, where it works on appetite regulation. It stimulates the release of norepinephrine and dopamine from the nerve, and its reuptake is inhibited. The increased norepinephrine may decrease hunger through a reduction in hungry messaging.

7-Keto DHEA^5,6

7-Keto-DHEA is believed to enhance thermogenesis (heat production) and basal metabolic rate by modulating the activity of 3 key metabolic enzymes, including: Glycerol-3-phosphate dehydrogenase, cytosolic malic enzyme, citrate lyase. These enzymes influence fatty acid oxidation and mitochondrial efficiency, contributing to increased energy expenditure by cells.

Calcium Pyruvate^10,12

Calcium pyruvate is used as a source of energy to produce ATP aerobically. It is metabolized in the Krebs cycle and converted to acetyl coenzyme A. It can be a source of energy anaerobically when it is converted to lactate.

Adverse Reactions

Phentermine^1,2

Gastrointestinal-dry mouth, diarrhea, constipation
Central nervous system-insomnia, dizziness, restlessness, nervousness, tremor, headache
Cardiovascular-tachycardia, increased blood pressure

7-Keto DHEA^5,6

Headache
Nausea or gastrointestinal upset
Mild dizziness
Irritability
Sleep disturbances (less common)

Because it does not convert into sex hormones, androgenic side effects (e.g., acne, hair loss, hirsutism) are rare or absent.

Calcium pyruvate⁹

Orally: Bloating, diarrhea.

Contraindications & Precautions

Contraindications

Phentermine^1,2

A known hypersensitivity to phentermine, 7-Keto DHEA, Calcium pyruvate or any of its ingredients
Contraindicated in pregnancy
Cardiovascular disease (coronary artery disease, arrhythmias, stroke, congestive heart failure, uncontrolled hypertension)
Hyperthyroidism
Glaucoma
History of drug abuse
Agitated states or severe anxiety disorders
Who have used monoamine oxidase inhibitors (MAOIs) within the past 14 days

7-Keto DHEA^5,6

Hypersensitivity to 7-keto-DHEA or any excipients in the product
Pregnancy or breastfeeding (insufficient safety data)

Precautions

Phentermine^1,2

Use with caution in patients with diabetes
Use cautiously in people operating machinery or driving a car

7-Keto DHEA^5,6

Use caution in individuals with autoimmune diseases due to theoretical immune-enhancing effects.
May interfere with thyroid function tests (e.g., T3/T4 levels); however, clinical significance is unclear.
People with hormone-sensitive conditions may still want to consult a healthcare provider, even though 7-keto-DHEA lacks direct hormonal activity.

Storage

Store at controlled room temperature 59-86°F (15-30°C). Protect from heat, light, and excessive humidity, and store in closed containers.

References

Phentermine Package insert. Revised March 2024. Accessed June 20, 2025. https://www.adipex.com/globalassets/adipex/adipex_pi.pdf
Clinical Pharmacology phentermine clinical monograph 2025 https://www.clinicalkey.com/pharmacology/
Elmaleh-Sachs A, Schwartz JL, Bramante CT, Nicklas JM, Gudzune KA, Jay M. Obesity Management in Adults: A Review. JAMA. 2023 Nov 28;330(20):2000-2015.
Phentermine https://www.ncbi.nlm.nih.gov/books/NBK547916/#Phentermine.OVERVIEW Accessed June 20, 2025.
7-Keto DHEA – Patient Handout; NatMed Pro; 2025; https://naturalmedicines-therapeuticresearch-com.lp.hscl.ufl.edu/databases/food,-herbs-supplements/patienthandout.aspx?productid=835&lang=en
7-Keto DHEA – Professional Monograph; NatMed Pro; 2025; https://naturalmedicines-therapeuticresearch-com.lp.hscl.ufl.edu/databases/food,-herbs-supplements/professional.aspx?productid=835
Douglas S. Kaiman, Carlon M. Colker, Melissa A. Swain, Georgeann C. Torina, Qiuhu Shi. A randomized, double-blind, placebo-controlled study of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy overweight adults. Current Therapeutic Research. Volume 61, Issue 7, 2000, 435-442.
Jeyaprakash N, Maeder S, Janka H, Stute P. A systematic review of the impact of 7-keto-DHEA on body weight. Arch Gynecol Obstet. 2023 Sep;308(3):777-785.
Nat Med Pyruvate accessed June 23, 2025.
Olek RA, Kujach S, Radak Z. Current knowledge about pyruvate supplementation: A brief review. Sports Med Health Sci. 2024 Feb 28;6(4):295-301.
Onakpoya I, Hunt K, Wider B, Ernst E. Pyruvate supplementation for weight loss: a systematic review and meta-analysis of randomized clinical trials. Crit Rev Food Sci Nutr. 2014;54(1):17-23.
Pyruvic Acid. Drug Bank Accessed June 29, 2025.

Disclaimer

This sheet is a summary. It may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.