Phentermine HCL Tablets

(Commercial Product)

Available Dosage Strengths

37.5 mg

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Product Overview

Phentermine HCL Tablets Description 1-4

Phentermine, a stimulant of the sympathetic central nervous system, is used as an anorectic. It is a schedule IV-controlled substance.  The drug closely mimics amphetamine in activity and structure. The drug is also an analog of methamphetamine. Phentermine can be used itself or combined in lower doses with other drugs to enhance its effect. The drug was been approved since 1959 and is used for the following indications:

  • For the treatment of obesity (short term use in combination with reduced calorie intake and lifestyle modifications) in patients with a body mass index of 30 kg/m2 or patients with a body mass index of 27 kg/m2 with a comorbidity of hypertension, diabetes or dyslipidemia.

References

  1. Phentermine Package insert. Revised March 2024. Accessed June 20, 2025. https://www.adipex.com/globalassets/adipex/adipex_pi.pdf
  2. Clinical Pharmacology phentermine clinical monograph 2025 https://www.clinicalkey.com/pharmacology/
  3. Elmaleh-Sachs A, Schwartz JL, Bramante CT, Nicklas JM, Gudzune KA, Jay M. Obesity Management in Adults: A Review. JAMA. 2023 Nov 28;330(20):2000-2015.
  4. Phentermine https://www.ncbi.nlm.nih.gov/books/NBK547916/#Phentermine.OVERVIEW Accessed June 20, 2025.

Mechanism of Action1,2

Phentermine predominantly acts in the central nervous system (CNS), within the hypothalamus and limbic systems, where it works on appetite regulation. It stimulates the release of norepinephrine and dopamine from the nerve, and its reuptake is inhibited. The increased norepinephrine may decrease hunger through a reduction in hungry messaging.

Common 1,2

  • Gastrointestinal-dry mouth, diarrhea, constipation
  • Central nervous system-insomnia, dizziness, restlessness, nervousness, tremor, headache
  • Cardiovascular-tachycardia, increased blood pressure

Contraindications 1,2

Phentermine is contraindicated in patients with:

  • A known hypersensitivity to phentermine or any of its ingredients
  • Contraindicated in pregnancy
  • Cardiovascular disease (coronary artery disease, arrhythmias, stroke, congestive heart failure, uncontrolled hypertension)
  • Hyperthyroidism
  • Glaucoma
  • History of drug abuse
  • Agitated states or severe anxiety disorders
  • Who have used monoamine oxidase inhibitors (MAOIs) within the past 14 days

Precautions 1,2

  • Use with caution in patients with diabetes
  • Use cautiously in people operating machinery or driving a car
  • Store at controlled room temperature (20°C to 25°C / 68°F to 77°F)
  • Protect from moisture and light
  • Keep in a tightly closed container
  1. Phentermine Package insert. Revised March 2024. Accessed June 20, 2025. https://www.adipex.com/globalassets/adipex/adipex_pi.pdf
  2. Clinical Pharmacology phentermine clinical monograph 2025 https://www.clinicalkey.com/pharmacology/
  3. Elmaleh-Sachs A, Schwartz JL, Bramante CT, Nicklas JM, Gudzune KA, Jay M. Obesity Management in Adults: A Review. JAMA. 2023 Nov 28;330(20):2000-2015.
  4. Phentermine https://www.ncbi.nlm.nih.gov/books/NBK547916/#Phentermine.OVERVIEW Accessed June 20, 2025.

This information is for educational purposes only.

Wells Pharmacy Network distributes certain FDA-approved commercial products that are manufactured by third-party pharmaceutical companies. These products are not compounded or manufactured by Wells Pharmacy Network. Product availability at the time of dispensing may vary due to supply chain conditions.

This information is a summary. It may not cover all possible drug information about this product. For complete product information, refer to the manufacturer’s prescribing information and labeling. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088.  A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.

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