Available Dosage Strengths
5 mg | 10 mg | 25 mg | 50 mg
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Dehydroepiandrosterone (DHEA) is an endogenous steroid hormone produced primarily in the adrenal cortex, with minor synthesis in the gonads and brain. It serves as a precursor to both androgens and estrogens, including testosterone and estradiol. DHEA levels naturally decline with age, and supplementation is used for age-related hormone decline, adrenal insufficiency, mood support, and sexual health.
Transdermal DHEA is compounded in a cream or gel base for application to the skin, allowing systemic absorption while bypassing hepatic first-pass metabolism. This route may reduce side effects and allow more stable hormone levels compared to oral DHEA.
DHEA is a prohormone, meaning its physiological effects are largely mediated through conversion to active androgens (like testosterone) and estrogens (like estradiol).
Endocrine effects:
In peripheral tissues, DHEA is converted to androstenedione, then to testosterone, estrone, and estradiol via tissue-specific enzymes such as 3β-HSD, 17β-HSD, aromatase.
Neurosteroid activity:
DHEA may interact with GABA-A and NMDA receptors, contributing to its neuromodulatory, antidepressant, and anxiolytic properties.
Contraindications:
Precautions:
Mild to moderate:
Less common but notable:
This sheet is a summary. It may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.
