Tadalafil / Ginger Root Capsules

Available Dosage Strengths

7.5 mg / 190 mg

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Disclaimer: Images are for reference only; actual products may vary.

Product Overview

Description

Tadalafil^1-3

Tadalafil, a phosphodiesterase type 5 (PDE5) inhibitor, has a mean terminal half-life of over 17 hours. This half-life is much longer than other PDE-5 inhibitors. This half-life allows for once-daily or on-demand dosing. The drug is indicated for the treatment of pulmonary arterial hypertension (PAH), erectile dysfunction (ED), benign prostatic hypertrophy (BPH), or the concurrent treatment of ED and BPH.

Ginger Root^4-7

Ginger root is the rhizome of the plant Zingiber officinale, widely used as both a culinary spice and a medicinal agent in traditional and modern medicine. It has been used historically in Ayurveda, Traditional Chinese Medicine, and Western herbalism for digestive aid, anti-inflammatory support, and circulatory stimulation.

Mechanism of Action

Tadalafil^1-3

Phosphodiesterase (PDE) has many isoforms and is an enzyme that has many functions in the body including degrading the effect of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). PDE5 is an enzyme that is found in many parts of the body including in the smooth muscle of the corpus cavernosum, prostate, bladder, the vascular and visceral smooth muscle, skeletal muscle, urethra, platelets, kidney, lung, cerebellum, heart, liver, testis, seminal vesicle, and pancreas. Tadalafil is a selective inhibitor of PDE5, the enzyme responsible for the degradation of cGMP. The drug has selective activity on PDE5 than other phosphodiesterase isoforms. Tadalafil activity on PDE5 is more than 10,000-fold more than for PDE1, PDE2, PDE4, and PDE7 enzymes. Increased cGMP leads to smooth muscle relaxation in the corpus cavernosum which can help in maintaining an erection.

Ginger Root^4-7

Ginger exerts its circulatory benefits through several pharmacological actions:

Vasodilation

Ginger’s active components, such as gingerols and shogaols, may promote vasodilation by stimulating nitric oxide (NO) synthesis and reducing vascular resistance.
Nitric oxide causes smooth muscle relaxation in blood vessels, enhancing blood flow.

Anti-Platelet Activity

Ginger inhibits thromboxane A2 and reduces platelet aggregation, potentially supporting microvascular perfusion and preventing clot formation.
This effect is comparable in mild strength to low-dose aspirin in some in vitro models.

Anti-Inflammatory and Antioxidant Effects

By suppressing COX-2 and reducing oxidative stress, ginger can improve endothelial function, which is often impaired in poor circulation states.

Metabolic Support

Ginger may modestly improve lipid profiles and glucose metabolism, which can indirectly benefit cardiovascular health and circulation.

Adverse Reactions

Common

Tadalafil¹

Headache
Dyspepsia
Flushing
Back pain and myalgia (typically delayed onset, resolving within 48 hours)
Nasal congestion
Pain in limbs

Ginger Root^4-7

Ginger is generally well-tolerated, especially in dosages up to 2 grams daily. However, potential side effects include:

Gastrointestinal distress (e.g., heartburn, gas, bloating, nausea at high doses)
Mild anticoagulant effects, which may increase bleeding risk
Hypotension or dizziness if taken in high doses with other vasodilators

Contraindications & Precautions

Tadalafil^1,2

Contraindications

Known hypersensitivity to tadalafil or excipients

Use of nitrates and guanylate cyclase (GC) stimulators therapy, such as riociguat due to risk of life-threatening hypotension

Precautions

Use with caution in patients with:

Severe hepatic impairment (Child-Pugh Class C)

Severe renal impairment (creatinine clearance <30 mL/min)

Retinitis pigmentosa (rare inherited retinal disorder)

History of NAION (non-arteritic anterior ischemic optic neuropathy)

Recent history of myocardial infarction, stroke, or unstable angina

Ginger Root^4-7

Use cautiously or avoid in the following populations:

Bleeding disorders or concurrent anticoagulant therapy
(e.g., warfarin, aspirin, apixaban): due to the additive risk of bleeding.
Preoperative patients: Ginger should be discontinued at least 1 week prior to surgery.
Gallstone disease: May increase bile flow.
Pregnancy: While commonly used for nausea, high doses may not be safe; consult a physician.
Allergy to ginger or related plants (e.g., turmeric)

Storage

Store at 20°C to 25°C (68°F to 77°F). Protect from light, moisture, and heat.

References

Tadalafil Prescribing Information – Eli Lilly. www.accessdata.fda.gov/drugsatfda_docs/label/2011/021368s20s21lbl.pdf Revised October 2011. Accessed May 31, 2025
Clinical Pharmacology Tadalafil clinical monograph 2025 https://www.clinicalkey.com/pharmacology/
Padda IS, Tripp J. Phosphodiesterase Inhibitors. [Updated 2023 Jun 26]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK559276/
Mashhadi NS, Ghiasvand R, Askari G, Hariri M, Darvishi L, Mofid MR. Anti-oxidative and anti-inflammatory effects of ginger in health and physical activity: review of current evidence. Int J Prev Med. 2013 Apr;4(Suppl 1):S36-42. PMID: 23717767; PMCID: PMC3665023
White B. “Ginger: an overview.” Am Fam Physician. 2007;75(11):1689-1691.
Verma SK, Singh J, Khamesra R, Bordia A. Effect of ginger on platelet aggregation in man. Indian J Med Res. 1993 Oct;98:240-2. PMID: 8119760.
Grzanna R, Lindmark L, Frondoza CG. “Ginger–an herbal medicinal product with broad anti-inflammatory actions.” J Med Food. 2005;8(2):125–132.

Disclaimer

This sheet is a summary. It may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.