Letrozole Tablets

Available Dosage Strengths

2.5 mg

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Product Overview

Description

Letrozole, an aromatase inhibitor (nonsteroidal), is used in postmenopausal women for breast cancer and for the treatment of advanced breast cancer. [1,2]

Mechanism of Action

Letrozole binds to heme group of the cytochrome P450 subunit of the aromatase (enzyme) resulting in a reduction of estrogen (estrone, estradiol and estrone sulfate) biosynthesis in all tissues. The drug decreases estrogen levels by preventing the conversion of androgens to estrogen. [1,2]

Adverse Reactions

Common

Hot flashes and sweating
Gastrointestinal (ie Nausea, vomiting, diarrhea, constipation, abdominal pain)
Musculoskeletal Disorders (ie Arthralgia, bone pain, and myalgia)
Headache
Dizziness
Bone pain [1]

Contraindications & Precautions

Contraindications

Known hypersensitivity to letrozole or any component of the formulation.

Letrozole is contraindicated during pregnancy.

Precautions

Reduction in bone mineral density
Use letrozole with caution in patients with pre-existing hypercholesterolemia. [1,2]

Storage

Store Letrozole Tablets at controlled room temperature, between 68°F to 77°F (20°C to 25°C). [1]

References

Femara (letrozole) package insert. East Hanover, NJ: Novartis Pharmaceuticals Corporation; https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020726s035lbl.pdf Revised April 2018. Accessed 05/21/2025
Clinical Pharmacology letrozole clinical monograph 2025 https://www.clinicalkey.com/pharmacology/

Disclaimer

This sheet is a summary. It may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.