Letrozole Tablets

Available Dosage Strengths

2.5 mg

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Product Overview

Description

Letrozole Tablets Description^1,2

Letrozole, an aromatase inhibitor (nonsteroidal), is used in postmenopausal women for breast cancer and for the treatment of advanced breast cancer.

Mechanism of Action

Mechanism of Action^1,2

Letrozole binds to heme group of the cytochrome P450 subunit of the aromatase (enzyme) resulting in a reduction of estrogen (estrone, estradiol and estrone sulfate) biosynthesis in all tissues. The drug decreases estrogen levels by preventing the conversion of androgens to estrogen.

Adverse Reactions

Common¹

Hot flashes and sweating
Gastrointestinal (ie Nausea, vomiting, diarrhea, constipation, abdominal pain)
Musculoskeletal Disorders (ie Arthralgia, bone pain, and myalgia)
Headache
Dizziness
Bone pain

Contraindications & Precautions

Contraindications^1,2

Known hypersensitivity to letrozole or any component of the formulation
Letrozole is contraindicated during pregnancy

Precautions^1,2

Reduction in bone mineral density
Use letrozole with caution in patients with pre-existing hypercholesterolemia

Storage

Store Letrozole Tablets at controlled room temperature, between 68°F to 77°F (20°C to 25°C).

References

Femara (letrozole) package insert. East Hanover, NJ: Novartis Pharmaceuticals Corporation; https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020726s035lbl.pdf Revised April 2018. Accessed 05/21/2025
Clinical Pharmacology letrozole clinical monograph 2025 https://www.clinicalkey.com/pharmacology/

Disclaimer

Wells Pharmacy Network is a 503B-registered outsourcing facility that compounds sterile medications in accordance with current good manufacturing practices (cGMP). Certain FDA-approved products referenced on this site are distributed separately from compounded preparations and are not manufactured by Wells Pharmacy Network.

This information may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.