Testosterone Cypionate / Anastrolzole Injection

Available Dosage Strengths

200 mg / 1 mg/mL | 200 mg/mL / 0.5 mg/mL

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Disclaimer: Images are for reference only; actual products may vary.

Testosterone Cypionate Anastrolzole Injection

Product Overview

Description

Testosterone Cypionate/Anastrozole is a combination of a steroid hormone testosterone an aromatase inhibitor (Anastrozole).

Testosterone Cypionate Description^1-5

Testosterone Cypionate is an esterified form of testosterone. The ester extends the duration of action and is useful for less frequent, intramuscular, or subcutaneous injections. Once administered, the ester is cleaved, releasing free testosterone into the bloodstream.

Anastrozole^6-8

Anastrozole is a selective non-steroidal aromatase inhibitor. The aromatase enzyme converts testosterone to estrogen. It may be used to prevent testosterone from being converted into estrogen

Mechanism of Action

Testosterone Cypionate^1-5

Testosterone then binds to androgen receptors in various tissues, exerting anabolic and androgenic effects. These effects include the development and maintenance of male secondary sexual characteristics, stimulation of muscle and bone growth, and regulation of libido and mood.

Anastrozole^6-8

In men that have low testosterone, anastrozole can be used to suppress estrogen biosynthesis in peripheral tissues by inhibiting the aromatase enzyme. Therapeutically, this inhibition results in decreased systemic estrogen levels and increased systemic testosterone levels. This helps keep testosterone levels in the therapeutic range.

Adverse Reactions

Common^1,3,4,6,7

Acne
Hypertension
Gastrointestinal (nausea, vomiting, abdominal pain)
Headache
Weight gain
Osteopenia
Insomnia
Injection site pain or inflammation
Mood swings or irritability
Increased or decreased libido
Gynecomastia

Contraindications & Precautions

Contraindications^1,3,4,6,7

Known intolerance or hypersensitivity to testosterone or anastrozole or any component of the formulation
Males with carcinoma of the breast or known or suspected carcinoma of the prostate
Pregnant or breastfeeding women
Patients with serious cardiac, hepatic, or renal disease

Precautions^1,3,4,6,7

Use with caution in patients with pre-existing hypercholesterolemia
Use with caution in patients with pre-existing osteoporosis; consider bone mineral density (BMD) monitoring in patients treated with anastrozole
Not recommended in patients who are pregnant
Use with caution in patients with pre-existing ischemic cardiac disease
Monitor hematocrit and hemoglobin levels
Regularly assess liver function tests
Evaluate lipid profiles periodically
Monitor for signs of sleep apnea
Use cautiously in patients with a history of cardiovascular disease

Storage

Store at 20°C to 25°C (68°F to 77°F) in a dry place, away from heat and light. DO NOT REFRIGERATE. Do not freeze. Keep out of reach of children.

References

Clinical Pharmacology Testosterone clinical monograph accessed May 8 2025 ; https://www.clinicalkey.com/pharmacology/monograph/595?n=Testosterone
Testosterone cypionate. Testosterone cypionate: Uses, Interactions, Mechanism of Action | DrugBank Online. https://go.drugbank.com/drugs/DB13943 Accessed September 30, 2025
Mayo Clinic. Testosterone cypionate (intramuscular route). https://www.mayoclinic.org/drugs-supplements/testosterone-cypionate-intramuscular-route/description/drg-20563731
Depo Testosterone(Testosterone Cypionate) [package insert] Pfizer Inc NY, NY 10017, revised July 2018, accessed May 2025 through: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/085635s040lbl.pdf
Punjani N, Bernie H, Salter C, Flores J, Benfante N, Mulhall JP. The Utilization and Impact of Aromatase Inhibitor Therapy in Men With Elevated Estradiol Levels on Testosterone Therapy. Sex Med. 2021 Aug;9(4):100378.
Clinical Pharmacology anastrozole clinical monograph 2025 https://www.clinicalkey.com/pharmacology/
de Ronde W, de Jong FH. Aromatase inhibitors in men: effects and therapeutic options. Reprod Biol Endocrinol. 2011 Jun 21;9:93.
Anastrozole (Ascend Laboratories, LLC): FDA Package Insert. https://medlibrary.org/lib/rx/meds/anstrozole-15/. Anastrozole package insert. Revised 03/11 Accessed May 20, 2025

Disclaimer

This information is for educational purposes only. This compounded product has not been reviewed, approved, or evaluated by the Food and Drug Administration for safety and effectiveness. This product is not intended to diagnose, treat, cure, or prevent any disease. No claims are made regarding treatment, cure, or prevention of any disease or condition.

This information may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.