Sildenafil / Aminophylline / Arginine / Testosterone Cream

Available Dosage Strengths

2% / 3% / 6% / 0.1%

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Disclaimer: Images are for reference only; actual products may vary.

Product Overview

Compounded Sildenafil_Aminophylline_Arginine_Testosterone Cream is a topical formulation designed to enhance libido, sex arousal and genital sensitivity. The cream may improve blood flow to the genital tissues, and testosterone, an androgen for hormonal balance. This cream is typically applied to the vulvar or clitoral area before sexual activity to promote arousal, increase lubrication, and enhance orgasmic response in women experiencing Female Sexual Arousal Disorder (FSAD) or to help erectile dysfunction in men. 1-13

Sildenafil1-5

Sildenafil, a phosphodiesterase type 5 (PDE5) inhibitor, has a half-life of 4 hours. Clinically, the drug is used to treat erectile dysfunction and pulmonary hypertension. Studies have shown it may also be beneficial for female sexual arousal disorder. Orally, because of the half-life, the drug is used “on-demand” prior to sexual activity.

Aminophylline6,7

Aminophylline is a complex of theophylline and ethylenediamine. This combination enhances the drugs solubility. Aminophylline has been used historically for asthma and chronic obstructive pulmonary disease and apnea of prematurity. It is thought to have vasodilatory activity. The drug may also have cardiac and diuretic effects. It may have several modes of activity in the body including 1) inhibition of type III or type IV phosphodiesterase (PDE), increased expression of calcium ion concentration in smooth muscle, inhibition of histamine release and antagonizing adenosine.

Arginine8,9

L-Arginine, an essential amino acid, is converted to nitric oxide. It is naturally found in red meat, poultry, fish, and dairy. Nitric oxide has been found to be a powerful vasodilator and neurotransmitter. Arginine supports protein synthesis, immune function and wound healing.

Testosterone10-13 

Micronized testosterone (natural) is derived from plants, most commonly, yams. This starting material undergoes a synthetic process to bioidentical testosterone. Unlike injectable testosterone, free testosterone is metabolized rapidly after absorption, requiring more frequent administration opposed to the weekly-monthly injections (cypionate, enanthate etc…). It has been studied for its potential role in treating male hypogonadism that is due to low testosterone and improve libido in both men and women. Micronized testosterone is used for compounded dosage forms including transdermal creams.

Sildenafil1-4

Phosphodiesterase (PDE) has many isoforms and is an enzyme that has many functions in the body including degrading the effect of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). PDE5 is an enzyme that is found in many parts of the body including in the smooth muscle of the corpus cavernosum, prostate, bladder, the vascular and visceral smooth muscle, skeletal muscle, urethra, platelets, kidney, lung, cerebellum, heart, liver, testis, seminal vesicle, and pancreas. Sildenafil is structurally similar to cGMP and prevents degradation of cGMP by competitively binding and inhibiting activity of PDE5. When PDE5 is inhibited, cGMP accumulates and leads to smooth muscle relaxation. Studies have shown that sildenafil facilitates the relaxation of the clitoral corpus cavernosum through the nitric oxide-cGMP pathway. This may improve genital blood flow and vaginal engorgement.

Aminophylline6,7

Phosphodiesterase activity-Inhibits phosphodiesterase (PDE), leading to increased intracellular cyclic AMP (cAMP) levels. Elevated cAMP may promote smooth muscle relaxation and vasodilation, improving blood flow to applied areas.

Nonselective adenosine receptor antagonist-It acts on A1, A2, and A3 receptors with similar affinity which may explain the drug’s cardiac effects. Adenosine-mediated channels also increase the contraction force of diaphragmatic muscles by enhancing their calcium uptake.

Arginine8,9

L-Arginine is necessary for making proteins and is commonly used to promote circulation. The body converts arginine to nitric oxide (NO) through the action of nitric oxide synthase which may relax blood vessels, allowing blood to flow.

Testosterone10-13 

Testosterone binds to androgen receptors in various tissues, exerting anabolic and androgenic effects. Testosterone may have a role in the development and maintenance of male secondary sexual characteristics, stimulation of muscle and bone growth, and regulation of libido and mood in both men and women.

Common  (topically) 5,7,8,9,10

  • Application site erythema
  • Application site discomfort
  • Itching, burning
  • Rash, pruritic
  • Headache

Rare

  • Anaphylactoid reactions, exfoliative dermatitis (ethylenediamine)

Oral (sildenafil)  

  • Flushing
  • Dyspepsia
  • Nasal congestion
  • Dizziness

Contraindications:  5,7,8,9,10

  • Known hypersensitivity or intolerance to sildenafil, aminophylline, arginine or testosterone
  • Use of nitrates and alpha-blockers due to risk of life-threatening hypotension

Precautions:

  • Use with caution in patients with:
  • Severe hepatic impairment (Child-Pugh Class C)
  • Severe renal impairment (creatinine clearance <30 mL/min)
  • History of NAION (non-arteritic anterior ischemic optic neuropathy)
  • Recent history of myocardial infarction, stroke, or unstable angina

Store at 20–25°C (68–77°F). Protect from excessive heat, light, and moisture.

  1. Sildenafil Prescribing Information – Pfizer. www.accessdata.fda.gov/drugsatfda_docs/label/2011/021368s20s21lbl.pdf Revised March 2014. Accessed May 31, 2025
  2. Clinical Pharmacology Sildenafil clinical monograph 2025 https://www.clinicalkey.com/pharmacology/
  3. Smith BP, Babos M. Sildenafil. [Updated 2023 Feb 14]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK558978/  
  4. Alatas E, Yagci AB. The effect of sildenafil citrate on uterine and clitoral arterial blood flow in postmenopausal women. MedGenMed. 2004 Oct 13;6(4):51. PMID: 15775878; PMCID: PMC1480594.
  5. Thurman AR, Johnson I, Cornell KA, Hatheway J, Kim NN, Parish SJ, Dart C, Friend DR, Goldstein A. Safety of topical sildenafil cream, 3.6% in a randomized, placebo-controlled trial for the treatment of female sexual arousal disorder. J Sex Med. 2024 Sep 3;21(9):793-799.
  6. Jilani TN, Preuss CV, Sharma S. Theophylline. StatPearls. May 1, 2023. Accessed August 7, 2025
  7. Clinical Pharmacology Aminophylline clinical monograph 2025 https://www.clinicalkey.com/pharmacology/
  8. L-Arginine – Patient Handout; NatMed Pro; 2025; https://naturalmedicines-therapeuticresearch-com.lp.hscl.ufl.edu/databases/food,-herbs-supplements/patienthandout.aspx?productid=875&lang=en
  9. Oyovwi MO, Atere AD. Exploring the medicinal significance of l-Arginine mediated nitric oxide in preventing health disorders. European Journal of Medicinal Chemistry Reports.Volume 12,2024:100175.
  10. Clinical Pharmacology Testosterone clinical monograph accessed June 17 2025; https://www.clinicalkey.com/pharmacology/monograph/595?n=Testosterone
  11. Tauchen J, Jurášek M, Huml L, Rimpelová S. Medicinal Use of Testosterone and Related Steroids Revisited. Molecules. 2021 Feb 15;26(4):1032. doi: 10.3390/molecules26041032. PMID: 33672087; PMCID: PMC7919692.
  12. AndroGel (testosterone gel 1.62% for topical use) [package insert] AbbVie US LLC , revised May 2013, accessed June 2025 through: https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021015s036lbl.pdf https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/085635s040lbl.pdf
  13. Clayton AH, Goldstein I, Kim NN, Althof SE, Faubion SS, Faught BM, Parish SJ, Simon JA, Vignozzi L, Christiansen K, Davis SR, Freedman MA, Kingsberg SA, Kirana PS, Larkin L, McCabe M, Sadovsky R. The International Society for the Study of Women’s Sexual Health Process of Care for Management of Hypoactive Sexual Desire Disorder in Women. Mayo Clin Proc. 2018 Apr;93(4):467-487. doi: 10.1016/j.mayocp.2017.11.002. Epub 2018 Mar 12. PMID: 29545008.

This information is for educational purposes only. This compounded product has not been reviewed, approved, or evaluated by the Food and Drug Administration for safety and effectiveness. This product is not intended to diagnose, treat, cure, or prevent any disease. No claims are made regarding treatment, cure, or prevention of any disease or condition.

This information may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088.  A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.

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