Available Dosage Strengths
50 mg | 100 mg
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Description 1-3
Micronized progesterone is a bioidentical form of the naturally occurring hormone progesterone, formulated into micron-sized particles to enhance oral absorption. It is used in various clinical settings within women’s health, including hormone replacement therapy (HRT), management of luteal phase defects, menstrual disorders, infertility treatments, and prevention of endometrial hyperplasia in postmenopausal women receiving estrogen therapy. Progesterone can be implanted subcutaneously through a compounded pellet to administer continuous progesterone over a period of typically 3 months.
Mechanism of Action 1-3
Progesterone is a steroid hormone primarily secreted by the corpus luteum and, during pregnancy, the placenta, it binds PR-A & PR-B receptors and the primary actions in women include:
– Endometrial transformation: Converts the endometrium from a proliferative to a secretory state, supporting implantation and pregnancy.
– Regulation of gonadotropin secretion: Via negative feedback on the hypothalamic-pituitary axis.
– Stabilization of the endometrium helps to prevent irregular bleeding in women receiving estrogen therapy.
– CNS effects: Modulates mood, sleep, and neuroprotective pathways through GABA-A receptor modulation.
Common Adverse Reactions 1-3
– Drowsiness or sedation
– Breast tenderness
– Headache
– Bloating
– Mood changes
– Irregular bleeding or spotting
– Dizziness
Contraindications and Precautions 1-3
Contraindications
Micronized progesterone should not be used in individuals with:
– Known or suspected pregnancy (when used outside pregnancy-supporting protocols)
– Undiagnosed abnormal menstrual bleeding
– Known, suspected, or history of breast cancer
– Active or history of thromboembolic disorders (stroke, DVT, heart attack etc…)
– Liver dysfunction or disease
– Hypersensitivity to progesterone or any formulation components
Precautions
– Use in patients with a history of depression should be monitored closely.
– Caution in cardiovascular disease, migraine, or seizure disorders.
– In women with a uterus, progesterone is required alongside estrogen to prevent endometrial hyperplasia.
Store at 20°C to 25°C (68°F to 77°F) in a dry place, away from heat and light. Keep out of reach of children.
This sheet is a summary. It may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.
