Phendimetrazine Tartrate Tablets

(Commercial Product)

Available Dosage Strengths

35 mg

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Disclaimer: Images are for reference only; actual products may vary.

Product Overview

Description

Phendimetrazine Tartrate Description^1,2

Phendimetrazine, a stimulant of the sympathetic central nervous system, is used as an anorectic. It is a schedule III-controlled substance. The drug closely mimics amphetamine in activity and structure. The drug has been approved since 1959. It is FDA approved for the following indication:

In the management of exogenous obesity as a short-term adjunct (a few weeks) in a regimen of weight reduction based on caloric restriction in patients with an initial body mass index (BMI) of 30 kg/m or higher who have not responded to appropriate weight reducing regimen (diet and/or exercise) alone.

Mechanism of Action

Mechanism of Action^1,2

Phendimetrazine predominantly acts in the central nervous system (CNS), within the hypothalamus and limbic systems, where it works on appetite regulation. It stimulates the release of norepinephrine and dopamine from the nerve, and its reuptake is inhibited. The increased norepinephrine may decrease hunger through a reduction in hungry messaging.

Adverse Reactions

Common^1,2

Gastrointestinal-dry mouth, diarrhea, constipation
Central nervous system-insomnia, dizziness, restlessness, nervousness, tremor, headache
Cardiovascular-tachycardia, increased blood pressure

Contraindications & Precautions

Contraindications^1,2

Phentermine is contraindicated in patients with:

A known hypersensitivity or intolerance to phendimetrazine or any of its ingredients
Contraindicated in pregnancy
Cardiovascular disease (coronary artery disease, arrhythmias, stroke, congestive heart failure, uncontrolled hypertension)
Hyperthyroidism
Glaucoma
History of drug abuse
Agitated states or severe anxiety disorders
Who have used monoamine oxidase inhibitors (MAOIs) within the past 14 days

Precautions^1,2

Use with caution in patients with diabetes
Use cautiously in people operating machinery or driving a car

Storage

Store tablets at controlled room temperature 68-77°F (20-25°C). Protect from heat, light, and excessive humidity, and store in closed containers. Keep out of reach of children and pets.

References

Phendimetrazine Package insert. Revised July 2016. Accessed August 31, 2025. file:///C:/Users/jdougherty/Downloads/20160719_37b5963b-0bbe-073e-e054-00144ff8d46c.pdf
Clinical Pharmacology phendimetrazine clinical monograph 2025 https://www.clinicalkey.com/pharmacology/

Disclaimer

This information is for educational purposes only. This compounded product has not been reviewed, approved, or evaluated by the Food and Drug Administration for safety and effectiveness. This product is not intended to diagnose, treat, cure, or prevent any disease. No claims are made regarding treatment, cure, or prevention of any disease or condition.

This information may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.