Ondansetron Tablets

(Commercial Product)

Available Dosage Strengths

4 mg | 8 mg

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Product Overview

Description

Ondansetron, a 5-HT₃ receptor antagonist, that is used clinically as an antiemetic. It prevents and treats nausea and vomiting specifically for patients on chemotherapy, receiving radiation or after surgery or after a medical procedure.

Mechanisms of Action

Serotonin (5-HT₃) receptors are found in the gastrointestinal tract and centrally in the chemoreceptor trigger zone (CTZ) in the brain. Ondansetron prevents serotonin from binding to serotonin receptors in the gastrointestinal tract and the chemoreceptor trigger zone. By preventing serotonin from binding to these receptors, it inhibits vomiting reflexes, specifically when chemotherapy, radiation, and anesthesia is administered.

Adverse Reactions

Common

Headache
Constipation
Fatigue
Dizziness

Contraindications & Precautions

Contraindications

Known hypersensitivity to ondansetron or other 5-HT₃ antagonists.

Precautions

QT interval prolongation: avoid in patients with risk factors for QT prolongation including congenital long QT syndrome or electrolyte imbalances. (hypokalemia, hypomagnesemia)—QT interval prolongation can lead to torsades de pointes.
Hepatic impairment: In severe hepatic dysfunction, do not exceed 8 mg total daily dose.

Storage

Tablets and ODTs: Store at 20–25°C (68–77°F); brief excursions permitted between 15–30°C (59–86°F). Injection: Store at controlled room temperature; protect from light. Store in tightly closed containers, away from moisture and excessive heat.

References

FDA Label – Ondansetron HCL. https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/020103s035_020605s019_020781s019lbl.pdf Revised October 2016 Accessed May 22, 2025.
Clinical Pharmacology ondansetron clinical monograph 2025 https://www.clinicalkey.com/pharmacology/

Disclaimer

This sheet is a summary. It may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.