Available Dosage Strengths
Sterile Powder 500 mg/Vial Injection Kit
Want to Prescribe?
(1) Nicotinamide Riboside Chloride (Niagen® Plus) Powder for Injection (500 mg vial)
(1) Bacteriostatic Water for Injection (30 mL vial)
Mixing Syringe (comes in two pieces):
• (1) 10 mL Mixing Syringe (without needle)
• (1) 22-Gauge Sterile Needle (do not use to administer subcutaneous injection)
(10) 1 mL Syringes (for administration use)
(20) Alcohol Prep Pads
Nicotinamide Riboside Chloride (NRCl) (NIAGEN® Plus) is a form of vitamin B3 that is involved in making energy in the body. NR is a precursor to NAD+ (nicotinamide adenine dinucleotide), and its administration increases NAD+ levels in the body. NAD+ is an essential coenzyme present in all cells in the body and is involved in more than 500 cellular functions. NAD+ has been shown to decline with age, which is likely the result of the accumulation of metabolic insults over time. NAD+ may also be lower in individuals with chronic illnesses. As an NAD+ precursor (building block), NR administration may be beneficial to overall wellness and supporting healthy aging. NIAGEN® Plus (NR Chloride, NRCl) is a proprietary, sterile form of NR used for injection or intravenous infusion.
In addition to other screening parameters, consideration should be given to patients with the following conditions:
The use of NIAGEN® Plus in children has not been studied; therefore, its use in children is not recommended.
Though the following have been observed in one or more individuals, each individual is unique and such experiences may or may not be experienced by the patient. The following side effects have been observed in participants who were prescribed NIAGEN® Plus:
This list may not describe all possible side effects. Side effects from NIAGEN® Plus usually will resolve on their own. However, please seek medical attention for side effects that persist or are bothersome.
To report side effects of any drug, contact FDA’s toll-free information line, 1-888-INFO-FDA (1-888-463-6332). Press 2 to report into MedWatch or to receive instructions.
Monitoring Parameters while using NIAGEN® Plus
If any of the following occur during therapy, discontinue use of NIAGEN® Plus, symptomatically treat, and/or provide immediate medical attention:
Preparation (Steps 1–4)
1. Thoroughly wash hands using soap and hot water. Dry hands completely.
2. Remove the plastic safety cap from one vial.
3. Using an alcohol prep pad, thoroughly wipe the rubber stopper.
4. Repeat steps 2-3 on the second vial.
Mixing (Steps 5–9)
5. Attach the 22-Gauge Sterile Needle to the 10mL Mixing Syringe to assemble the Mixing Syringe.
6. Using the Mixing Syringe, draw the volume of bacteriostatic water indicated in the Table in your written instructions, according to the concentration prescribed by your health care provider.
IMPORTANT: Do not reconstitute Niagen® Plus Sterile Powder with less than 5mL of bacteriostatic water.
7. Inject the prescribed volume of bacteriostatic water from the Mixing Syringe into the Nicotinamide Riboside Chloride (Niagen® Plus) Powder for Injection 500mg vial.
8. Remove the Mixing Syringe and gently swirl the vial until the powder dissolves completely.
IMPORTANT: Discard the Mixing Syringe needle in a Sharps Container. Review your state/city regulations on safe needle disposal or consult your prescriber.
9. Verify the solution is clear, colorless, and free of particulates before use.
Storing (Steps 10–11)
10. Refrigerate the reconstituted solution and store refrigerated between injections.
11. Discard any remaining contents after the 28-day beyond-use date.
This information is for educational purposes only. This compounded product has not been reviewed, approved, or evaluated by the Food and Drug Administration for safety and effectiveness. This product is not intended to diagnose, treat, cure, or prevent any disease. No claims are made regarding treatment, cure, or prevention of any disease or condition.
This information may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.
