N-DIM

(Commercial Product)

Available Dosage Strengths

200 mg

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Product Overview

Description

N-Diindolylmethane (DIM) is a naturally occurring compound derived from the digestion of indole-3-carbinol (I3C), which is found in cruciferous vegetables such as broccoli, brussels sprouts, and kale. DIM is often used as a dietary supplement or compounded into oral capsules or topical formulations for its potential hormonal balancing, anti-cancer, and anti-inflammatory effects.^1-6

Mechanism of Action

DIM may influence estrogen metabolism by shifting the breakdown of estradiol (E2) toward 2-hydroxyestrone (2-OHE1) instead of 16α-hydroxyestrone, a potentially pro-carcinogenic metabolite. carcinogenic metabolite. Scientific studies continue to investigate how this compound interacts with biological pathways, including:^1-6

DIM may act as a selective androgen receptor modulator (SARM), helping reduce androgen-driven conditions like acne and hormonal hair loss in some individuals.
Aromatase Inhibition (mild)
Some studies suggest DIM can mildly inhibit aromatase, the enzyme that converts testosterone to estradiol, making it of interest in estrogen-dominant or androgen-sensitive conditions.
Shown to have Anti-Inflammatory and Antioxidant Activity
May modulate NF-κB signaling, reducing inflammatory cytokine release. Has exhibited antioxidant properties, scavenging reactive oxygen species (ROS).
Shown to promote apoptosis (programmed cell death) and inhibit angiogenesis in certain cancer cells (in vitro)

Adverse Reactions

Common:^1-6

Headache
Nausea or gastrointestinal discomfort
Changes in urine color (darker, amber)
Fatigue
Contraindications and Precautions

Contraindications & Precautions

Contraindications:^1-6

Known intolerance or hypersensitivity to DIM or indole-containing compounds

Precautions:

Pregnancy and lactation: Not enough safety data; use caution or avoid unless under medical supervision
Hormone-sensitive conditions (e.g., breast cancer, endometriosis, fibroids): DIM may alter estrogen activity; consult healthcare provider before use.
Anticoagulant use: DIM may have mild antiplatelet effects; monitor bleeding risk.
Concurrent hormone therapy: DIM may alter efficacy of oral contraceptives or hormone replacement therapy (HRT).
May interact with cytochrome P450 enzymes, affecting metabolism of other drugs.

Storage

Store in a cool, dry place, away from direct light and heat; Room temperature (20°C–25°C / 68°F–77°F) is ideal. Keep out of reach of children and pets.

References

Zhang WW, Feng Z, Narod SA. Multiple therapeutic and preventive effects of 3,3′-diindolylmethane on cancers including prostate cancer and high grade prostatic intraepithelial neoplasia. J Biomed Res. 2014 Sep;28(5):339-48. doi: 10.7555/JBR.28.20140008. Epub 2014 Apr 20. PMID: 25332705; PMCID: PMC4197384.
Dallera CA, Placeres-Uray F, Mastromatteo-Alberga P, Dominguez-Torres M, Balleste AF, Gorthy AS, Rahimzadeh TS, Aliancin I, Dietrich WD, de Rivero Vaccari JP, Jacobs IC, Chlipala EA, Benton H, Zeligs MA, Atkins CM. 3,3′-Diindolylmethane improves pathology and neurological outcome following traumatic brain injury. Neurotherapeutics. 2025 Mar;22(2):e00531. doi: 10.1016/j.neurot.2025.e00531. Epub 2025 Feb 4. PMID: 39909809; PMCID: PMC12014418.
Biersack B. 3,3′-Diindolylmethane and its derivatives: nature-inspired strategies tackling drug resistant tumors by regulation of signal transduction, transcription factors and microRNAs. Cancer Drug Resist. 2020 Oct 12;3(4):867-878. doi: 10.20517/cdr.2020.53. PMID: 35582221; PMCID: PMC8992569.
Li Y, Kong D, Ahmad A, Bao B, Sarkar FH. Antioxidant function of isoflavone and 3,3′-diindolylmethane: are they important for cancer prevention and therapy? Antioxid Redox Signal. 2013 Jul 10;19(2):139-50. doi: 10.1089/ars.2013.5233. Epub 2013 Mar 14. PMID: 23391445; PMCID: PMC3689155.
Reyes-Hernández OD, Figueroa-González G, Quintas-Granados LI, Gutiérrez-Ruíz SC, Hernández-Parra H, Romero-Montero A, Del Prado-Audelo ML, Bernal-Chavez SA, Cortés H, Peña-Corona SI, Kiyekbayeva L, Ateşşahin DA, Goloshvili T, Leyva-Gómez G, Sharifi-Rad J. 3,3′-Diindolylmethane and indole-3-carbinol: potential therapeutic molecules for cancer chemoprevention and treatment via regulating cellular signaling pathways. Cancer Cell Int. 2023 Aug 26;23(1):180. doi: 10.1186/s12935-023-03031-4. PMID: 37633886; PMCID: PMC10464192.
Amare, D. E. (2020). Anti-cancer and other biological effects of a dietary compound 3, 3′-diindolylmethane supplementation: a systematic review of human clinical trials. Nutrition and Dietary Supplements, 123-137.

Disclaimer

This information is for educational purposes only. This compounded product has not been reviewed, approved, or evaluated by the Food and Drug Administration for safety and effectiveness. This product is not intended to diagnose, treat, cure, or prevent any disease. No claims are made regarding treatment, cure, or prevention of any disease or condition.

This information may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.