Available Dosage Strengths
0.5% / 1% / 50 IU/mL
Want to Prescribe?
Hyaluronic Acid_DHEA_Vitamin E Lubricating Gel is a compounded topical formulation designed to improve vaginal mucosal hydration, and support tissue comfort and elasticity. It can be used in individuals experiencing vaginal dryness from genitourinary syndrome of menopause (GSM) or other conditions that cause vaginal dryness. This combination supports vaginal health and comfort by facilitating moisture preservation and hormonal support.
Hyaluronic Acid1,2
Hyaluronic Acid, a glycosaminoglycan, has an important role for the skin. It can help maintain hydration, elasticity, and skin integrity. It also has a role in wound healing. As people age, the production of hyaluronic acid decreases, leading to drier and less elastic skin.
Dehydroepiandrosterone (DHEA)3,4,5
Dehydroepiandrosterone (DHEA) is an endogenous steroid hormone produced primarily in the adrenal cortex, with minor synthesis in the gonads and brain. It serves as a precursor to both androgens and estrogens, including testosterone and estradiol. DHEA levels naturally decline with age, and supplementation is used for age-related hormone decline, adrenal insufficiency, mood support, and sexual health.
Transdermal DHEA is compounded in a cream or gel base for application to the skin, allowing systemic absorption while bypassing hepatic first-pass metabolism. This route may reduce side effects and allow more stable hormone levels compared to oral DHEA.
Vitamin E6,7
Vitamin E (or tocopherol), a fat-soluble vitamin, that functions as an antioxidant, protecting the cell membrane. The body does not form vitamin E and needs to be provided it exogenously. Vitamin E may prevent reactive oxygen species from forming and protect the biosynthesis of collagen and glycosaminoglycans in skin. Vitamin E may benefit the following dermatological conditions: atopic dermatitis, epidermolysis bullosa, psoriasis, wound healing, melasma, scleroderma, acne vulgaris and melasma.
Hyaluronic Acid1,2
Hyaluronic acid is thought to work through two mechanisms 1) as a passive structural molecule and 2) as a signaling molecule (based on its molecular size). Hyaluronic acid has hydgroscopicity and viscoelasticity properties. It is highly anionic that can attract water. This attraction of water provides the ability of the skin to create volume and provide structural support. The signaling mechanism may be facilitated by its anti-inflammatory properties through its effects on cell migration and cell division.
DHEA3,4,5
DHEA is a prohormone, meaning its physiological effects are largely mediated through conversion to active androgens (like testosterone) and estrogens (like estradiol).
Endocrine effects:
Neurosteroid activity:
Vitamin E6,7
Gamma (γ) tocopherol is the most abundant vitamin E in the diet and alpha (α) tocopherol is the most abundant form of vitamin E in the skin. These forms of vitamin E are thought to inhibit the production of prostaglandin and nitric oxide, protect skin cells from sunburn and generally prevent oxidative stress in the skin.
Common: 1-7
Contraindications: 1-7
Precautions:
Store at room temperature (20–25°C or 68–77°F). Protect from light, heat, and moisture. Keep the tube or container tightly closed. Keep out of reach of children.
This information is for educational purposes only. This compounded product has not been reviewed, approved, or evaluated by the Food and Drug Administration for safety and effectiveness. This product is not intended to diagnose, treat, cure, or prevent any disease. No claims are made regarding treatment, cure, or prevention of any disease or condition.
This information may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.
