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Dehydroepiandrosterone (DHEA) is an endogenous steroid hormone produced primarily in the adrenal cortex, with minor synthesis in the gonads and brain. It serves as a precursor to both androgens and estrogens, including testosterone and estradiol. DHEA levels naturally decline with age, and supplementation is used for age-related hormone decline, adrenal insufficiency, mood support, and sexual health.
Transdermal DHEA is compounded in a cream or gel base for application to the skin, allowing systemic absorption while bypassing hepatic first-pass metabolism. This route may reduce side effects and allow more stable hormone levels compared to oral DHEA.
DHEA is a prohormone, meaning its physiological effects are largely mediated through conversion to active androgens (like testosterone) and estrogens (like estradiol).
Endocrine effects:
In peripheral tissues, DHEA is converted to androstenedione, then to testosterone, estrone, and estradiol via tissue-specific enzymes such as 3β-HSD, 17β-HSD, aromatase.
Neurosteroid activity:
DHEA may interact with GABA-A and NMDA receptors, contributing to its neuromodulatory, antidepressant, and anxiolytic properties.
Contraindications:
Precautions:
Mild to moderate:
Less common but notable:
This information is for educational purposes only. This compounded product has not been reviewed, approved, or evaluated by the Food and Drug Administration for safety and effectiveness. This product is not intended to diagnose, treat, cure, or prevent any disease. No claims are made regarding treatment, cure, or prevention of any disease or condition.
This information may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.
