DHEA SR Capsules in K100M

Available Dosage Strengths

5 mg | 10 mg | 25 mg | 50 mg

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Disclaimer: Images are for reference only; actual products may vary.

Product Overview

Description

DHEA SR Capsules in K100M Description^1-3

Dehydroepiandrosterone (DHEA) is an endogenous steroid hormone produced primarily in the adrenal cortex, with minor synthesis in the gonads and brain. It serves as a precursor to both androgens and estrogens, including testosterone and estradiol. DHEA levels naturally decline with age, and supplementation is used for age-related hormone decline, adrenal insufficiency, mood support, and sexual health.

Transdermal DHEA is compounded in a cream or gel base for application to the skin, allowing systemic absorption while bypassing hepatic first-pass metabolism. This route may reduce side effects and allow more stable hormone levels compared to oral DHEA.

Mechanism of Action

Mechanism of Action^1-3

DHEA is a prohormone, meaning its physiological effects are largely mediated through conversion to active androgens (like testosterone) and estrogens (like estradiol).

Endocrine effects:

In peripheral tissues, DHEA is converted to androstenedione, then to testosterone, estrone, and estradiol via tissue-specific enzymes such as 3β-HSD, 17β-HSD, aromatase.

Neurosteroid activity:

DHEA may interact with GABA-A and NMDA receptors, contributing to its neuromodulatory, antidepressant, and anxiolytic properties.

Contraindications & Precautions

Contraindications^1-3

Hormone-sensitive cancers (e.g., breast, prostate, uterine)
Pregnancy and breastfeeding (safety not established)
Known hypersensitivity to DHEA or transdermal base formulation

Precautions^1-3

May exacerbate androgen-sensitive conditions (e.g., acne, PCOS)
Monitor in individuals with bipolar disorder or psychiatric history due to possible mood effects
May interfere with hormone testing or HRT regimens
Caution in individuals with liver dysfunction, though transdermal avoids first-pass effect

Adverse Reactions

Mild to moderate^1-3

Acne
Oily skin
Increased facial or body hair (hirsutism)
Scalp hair thinning (in some women)
Body odor changes
Mood swings or irritability
Insomnia

Less common but notable^1-3

Menstrual irregularities
Breast tenderness
Deepening of voice (at higher doses in women)
Gynecomastia in men (from estrogenic conversion)
Libido changes

Storage

Store at room temperature (20°C–25°C / 68°F–77°F)
Keep away from direct sunlight, moisture, and heat
Keep tightly sealed and out of reach of children

References

DHEA – Patient Handout; NatMed Pro; 2025; https://naturalmedicines-therapeuticresearch-com.lp.hscl.ufl.edu/databases/food,-herbs-supplements/patienthandout.aspx?productid=331&lang=en
DHEA – Professional Monograph; NatMed Pro; 2025; https://naturalmedicines-therapeuticresearch-com.lp.hscl.ufl.edu/databases/food,-herbs-supplements/professional.aspx?productid=331
DHEA – Drugbank ; 2025; https://go.drugbank.com/categories/DBCAT001749

Disclaimer

This information is for educational purposes only. This compounded product has not been reviewed, approved, or evaluated by the Food and Drug Administration for safety and effectiveness. This product is not intended to diagnose, treat, cure, or prevent any disease. No claims are made regarding treatment, cure, or prevention of any disease or condition.

This information may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.