Bi-Test (Enanthate 75% / Cypionate 25%) Injection

Available Dosage Strengths

200 mg/mL

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Product Overview

Description

Bi-Test is a compounded injectable testosterone blend consisting of 75% testosterone enanthate and 25% testosterone cypionate. Both are long-acting testosterone esters used in testosterone replacement therapy (TRT) to treat male hypogonadism. This combination aims to leverage the pharmacokinetic profiles of both esters to provide a more stable and sustained release of testosterone, potentially reducing the frequency of injections and minimizing fluctuations in hormone levels.^1,2

Mechanisms of Action

Testosterone enanthate and testosterone cypionate are both esterified forms of testosterone, designed for intramuscular injection. Once administered, the esters are cleaved, releasing free testosterone into the bloodstream. Testosterone then binds to androgen receptors in various tissues, exerting anabolic and androgenic effects. These effects include the development and maintenance of male secondary sexual characteristics, stimulation of muscle and bone growth, and regulation of libido and mood.^1,2,3,4

Adverse Reactions

Acne
Hypertension
Injection site pain or inflammation
Mood swings or irritability
Increased or decreased libido
Gynecomastia

Contraindications & Precautions

Contraindications:

Known hypersensitivity to testosterone or either ester (cypionate or enanthate).
Known hypersensitivity to grapeseed oil.
Males with carcinoma of the breast or known or suspected carcinoma of the prostate.
Pregnant or breastfeeding women.
Patients with serious cardiac, hepatic, or renal disease.

Precautions:

Monitor hematocrit and hemoglobin levels.
Regularly assess liver function tests.
Evaluate lipid profiles periodically.
Monitor for signs of sleep apnea.
Use cautiously in patients with a history of cardiovascular disease.

Storage

Store Bi-Test at 20°C to 25°C (68°F to 77°F) in a dry place, away from heat and light. Do not freeze. Keep out of reach of children.^4,5

References

Clinical Pharmacology Testosterone clinical monograph accessed May 8 2025; https://www.clinicalkey.com/pharmacology/monograph/595?n=Testosterone
https://go.drugbank.com/drugs/DB13944
Mayo Clinic. Testosterone cypionate (intramuscular route). https://www.mayoclinic.org/drugs-supplements/testosterone-cypionate-intramuscular-route/description/drg-20563731
Testosterone enanthate [package insert] Hikma Pharmaceuticals USA Inc. Berkeley Heights, NJ 07922, revised January 2021, accessed May 08 2025 through: https://www.accessdata.fda.gov/spl/data/d56a5e5d-c88f-4f0d-84b4-1be06ca6ebba/d56a5e5d-c88f-4f0d-84b4-1be06ca6ebba.xml
Depo Testosterone(Testosterone Cypionate) [package insert] Pfizer Inc NY, NY 10017, revised July 2018, accessed May 08 2025 through: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/085635s040lbl.pdf

Disclaimer

This sheet is a summary. It may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.