Amiophylline / Arginine Gel

Available Dosage Strengths

3% / 6%

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Disclaimer: Images are for reference only; actual products may vary.

Product Overview

Description

Compounded Aminophylline/Arginine gel is a topical formulation designed to enhance female sexual arousal and genital sensitivity. It combines two active agents—aminophylline, a phosphodiesterase inhibitor, and L-arginine, a nitric oxide precursor—to improve blood flow to the genital tissues. This gel is typically applied to the vulvar or clitoral area before sexual activity to promote arousal, increase lubrication, and enhance orgasmic response in women experiencing Female Sexual Arousal Disorder (FSAD) or other forms of sexual dysfunction.

Mechanism of Action

Aminophylline:^1-5

A complex of theophylline and ethylenediamine.
Inhibits phosphodiesterase (PDE), leading to increased intracellular cyclic AMP (cAMP) levels.
Elevated cAMP promotes smooth muscle relaxation and vasodilation, improving blood flow to applied areas.
Has mild lipolytic properties, though this effect is more relevant in cosmetic applications.

L-Arginine:

A naturally occurring amino acid and precursor to nitric oxide (NO).
Nitric oxide may act as a vasodilator, increasing blood flow by relaxing vascular smooth muscle.
May enhance blood flow, which can increase clitoral and vulvar engorgement, contributing to improved sensitivity and sexual pleasure.

Combined Effect:

The combination of aminophylline and L-arginine may synergistically enhance genital blood flow, improving sexual responsiveness and local tissue sensitivity in women.

Adverse Reactions

Common (local):^1-5

Skin irritation (redness, itching, tingling)
Burning sensation at the application site
Allergic contact dermatitis (rare)

Systemic (uncommon but possible):^1-5

Nervousness or jitteriness (from aminophylline)
Headache
Nausea
Hypotension

Contraindications & Precautions

Contraindications:^1-5

Known allergy or hypersensitivity to aminophylline, theophylline, or L-arginine
Active genital infections (e.g., herpes, yeast infections)
Broken or inflamed skin at the application site

Precautions:^1-5

Use with caution in individuals with:
Cardiovascular disease (due to potential vasodilation)
Hypotension
Asthma or COPD (aminophylline may interact with systemic medications)
Pregnancy or breastfeeding (safety not established)
Not for use with barrier methods like latex condoms without compatibility testing, as some gels may degrade latex.

Storage

Store at 20–25°C (68–77°F) in a dry place, away from direct sunlight and heat. Do not refrigerate or freeze. Keep container tightly closed. Keep out of reach of children.

References

Clinical Pharmacology (Elsevier) – aminophylline 100mg tablet Monograph; accessed August 2025 through https://www.clinicalkey.com/pharmacology/monograph/599?aprid=7845
L-Arginine – Patient Handout; NatMed Pro; 2025; https://naturalmedicines-therapeuticresearch-com.lp.hscl.ufl.edu/databases/food,-herbs-supplements/patienthandout.aspx?productid=875&lang=en
Leiblum SR, Wiegel M. Psychotherapeutic interventions for treating female sexual dysfunction. World J Urol. 2002 Jun;20(2):127-36. doi: 10.1007/s00345-002-0266-3. Epub 2002 May 15. PMID: 12107544.
Basson R. Women’s sexual dysfunction: revised and expanded definitions. CMAJ. 2005 May 10;172(10):1327-33. doi: 10.1503/cmaj.1020174. PMID: 15883409; PMCID: PMC557105.
Meston CM, Frohlich PF. The neurobiology of sexual function. Arch Gen Psychiatry. 2000 Nov;57(11):1012-30. doi: 10.1001/archpsyc.57.11.1012. PMID: 11074867.

Disclaimer

This information is for educational purposes only. This compounded product has not been reviewed, approved, or evaluated by the Food and Drug Administration for safety and effectiveness. This product is not intended to diagnose, treat, cure, or prevent any disease. No claims are made regarding treatment, cure, or prevention of any disease or condition.

This information may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.