Glutathione-L Injection

(Ship Cold)

Available Dosage Strengths

200 mg/mL

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Product Overview

Description

Glutathione, a combination of three amino acids (cysteine, glycine, and glutamic acid), is a strong antioxidant that can be prescribed at the direction of your health care professional. It is involved in many regulatory functions in the body and helps to decrease toxins in the body and may improve immune function. It is found in large quantities in many cells in the body (1-10 millimoles/L). In the article, “Glutathione!, the many functions of glutathione are described as follows:^1-3

Direct chemical neutralization of singlet oxygen, hydroxyl radicals, and superoxide radicals
Cofactor for several antioxidant enzymes
Regeneration of vitamins C and E
Neutralization of free radicals produced by Phase I liver metabolism of chemical toxins
Involved in liver Phase II reactions, which conjugate the activated intermediates produced by Phase I to make them water soluble for excretion by the kidneys
Transportation of mercury out of cells and the brain
Regulation of cellular proliferation and apoptosis
Vital to mitochondrial function and maintenance of mitochondrial DNA (mtDNA)

Clinically, glutathione is thought to critical for the following disease and body processes”¹

Neurogenerative disorders (Alzheimer’s disease, Parkinson’s disease, Huntington’s diseases, amyotrophic lateral sclerosis, and Friedreich’s ataxia)
Pulmonary disease (chronic obstructive pulmonary disease, asthma, and acute respiratory distress syndrome)
Immune disease (HIV, autoimmune diseases)
Cardiovascular disease (hypertension, myocardial infarction, cholesterol oxidation)
Chronic age-related disease (cataracts, macular degeneration, hearing impairment, and glaucoma)
Liver disease
Cystic fibrosis
Aging process

Mechanism of Action

Glutathione has many mechanisms in the body to support its role as an antioxidant, a detoxifier, and its involvement in many enzymatic processes including redox reactions. Glutathione antioxidant effects include glutathione peroxidase-catalyzed reactions with the removal of hydrogen peroxide, organic peroxides, and peroxynitrite. Glutathione detoxifies by using glutathione transferases. These glutathione transferases also have antioxidant properties. Glutathione binds harmful substances, including heavy metals (like mercury, cadmium, lead, and arsenic), toxins from mold (mycotoxins), synthetic chemicals, and harmful free radicals. It neutralizes these toxins, making them more water-soluble and easier for the body to eliminate through urine or bile. Glutathione is made in the cytosol of the cell by two enzymes. The first enzyme is glutamate cysteine ligase. Glutamate cysteine ligase (GCL) catalyzes ligation of cysteine and glutamate forming γ-glutamylcysteine (γ-GC). The second enzyme is glutathione synthase. Glutathione synthase adds glycine to γ-GC resulting in glutathione formation.^1-4

Adverse Reactions

Common: ^5,6

Injection site reactions such as pain, redness, or swelling.

Nausea, diarrhea, or abdominal cramps.

Allergic reactions, including rashes (Stevens Johnson Syndrome)

Contraindications & Precautions

Contraindications: ^5,6

Known hypersensitivity to glutathione or any of its components

Precautions: ^5,6

Individuals with renal impairment

Storage

Store refrigerated at 36°F to 46°F (2°C – 8°C). Discard within 28 days of puncture or according to the beyond-use date. Do not freeze. Keep out of reach of children and pets.

References

Pizzorno J. Glutathione! Integr Med (Encinitas). 2014 Feb;13(1):8-12.
Lapenna D. Glutathione and glutathione-dependent enzymes: From biochemistry to gerontology and successful aging. Ageing Res Rev. 2023 Dec;92:102066.
Lushchak VI. Glutathione homeostasis and functions: potential targets for medical interventions. J Amino Acids. 2012;2012:736837.
DrugBank: Glutathione – Uses, Interactions, Mechanism of Action. https://go.drugbank.com/drugs/DB00143 Accessed July 16, 2025
Sonthalia S, Daulatabad D, Sarkar R. Glutathione as a skin whitening agent: Facts, myths, evidence and controversies. Indian J Dermatol Venereol Leprol. 2016 May-Jun;82(3):262-72.
Glutathione Injections – Are they for everyone? Safety and efficacy revealed. https://timesofindia.indiatimes.com/life-style/health-fitness/health-news/glutathione-injections-are-they-for-everyone-safety-and-efficacy-revealed/articleshow/122194582.cms July 2, 2025. Accessed July 16, 2025

Disclaimer

This sheet is a summary. It may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.