Depo® Testosterone Cypionate Injection, USP

(Commercial Product)

Available Dosage Strengths

200 mg/mL

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Disclaimer: Images are for reference only; actual products may vary.

Product Overview

Description

Depo® Testosterone Cypionate Injection, USP Description^1-4

Testosterone Cypionate Injection is a compounded injectable product used for testosterone replacement when there is a decline in testosterone levels as seen with hypogonadism and to support energy, mood and sexual health.

Testosterone cypionate is a long-acting testosterone ester. It has a half-life of 8 days. Testosterone that has not been esterified has a half-life of as short as 10 minutes. Thus, the esterification process increases the half-life dramatically.

Mechanism of Action

Mechanism of Action^1-4

Testosterone Cypionate is an esterified form of testosterone. The ester extends the duration of action and is useful for less frequent, intramuscular, or subcutaneous injections. Once administered, the ester is cleaved, releasing free testosterone into the bloodstream. Testosterone then binds to androgen receptors in various tissues, exerting anabolic and androgenic effects. These effects may include the development and maintenance of male secondary sexual characteristics, stimulation of muscle and bone growth, and regulation of libido and mood.

Adverse Reactions

Common^1-4

Acne
Hypertension
Gastrointestinal (nausea, vomiting, abdominal pain)
Headache
Weight gain
Insomnia
Injection site pain or inflammation
Mood swings or irritability
Increased or decreased libido
Gynecomastia

Contraindications & Precautions

Contraindications^1-4

Known hypersensitivity to testosterone, cypionate or any component of the formulation
Known hypersensitivity to cotton seed oil
Males with carcinoma of the breast or known or suspected carcinoma of the prostate
Pregnant or breastfeeding women
Patients with serious cardiac, hepatic, or renal disease

Precautions^1-4

Monitor hematocrit and hemoglobin levels.
Regularly assess liver function tests.
Evaluate lipid profiles periodically.
Monitor for signs of sleep apnea.
Use cautiously in patients with a history of cardiovascular disease.

Storage

Store at controlled room temperature (20°C to 25°C / 68°F to 77°F)
Protect from moisture and light
Keep in a tightly closed container

References

Clinical Pharmacology Testosterone clinical monograph accessed May 8 2025 ; https://www.clinicalkey.com/pharmacology/monograph/595?n=Testosterone
https://go.drugbank.com/drugs/DB13944
Mayo Clinic. Testosterone cypionate (intramuscular route). https://www.mayoclinic.org/drugs-supplements/testosterone-cypionate-intramuscular-route/description/drg-20563731
Depo Testosterone(Testosterone Cypionate) [package insert] Pfizer Inc NY, NY 10017, revised July 2018, accessed May 2025 through: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/085635s040lbl.pdf

Disclaimer

Wells Pharmacy Network is a 503B-registered outsourcing facility that compounds sterile medications in accordance with current good manufacturing practices (cGMP). Certain FDA-approved products referenced on this site are distributed separately from compounded preparations and are not manufactured by Wells Pharmacy Network. Actual products in stock at time of dispensing may vary due to supply chain variability.

This information may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.