Zinc Thymulin / GHK-Cu Spray

(Ship Cold)

Available Dosage Strengths

0.001% / 0.5%

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Product Overview

Description

Zinc-Thymulin^1-3

Zinc-Thymulin is an experimental topical compound consisting of zinc and thymulin, a nonapeptide originally isolated from the thymus. While thymulin alone is inactive without zinc, their combination may yield biological activity, particularly in the context of immune modulation and cell signaling. In topical applications, the compound has been explored for its potential to support healthy hair follicle function. Early preclinical and limited clinical observations suggest that zinc-thymulin may have a role in managing certain types of hair thinning or loss.

GHK-Cu⁴

GHK-Cu is a naturally occurring copper-binding peptide that plays a role in tissue remodeling and repair. It is composed of a tripeptide (glycine–histidine–lysine) complexed with copper (II). Endogenously present in human plasma, its levels decline with age.

Topical formulations of GHK-Cu are being used for their potential to support skin regeneration, improve skin appearance, and promote scalp health. There is some evidence that the peptide may also influence hair follicle growth.

Mechanism of Action

Zinc-Thymulin^1-3

Though the precise mechanisms are not fully elucidated, zinc-thymulin is thought to exert its effects through several possible pathways:

Modulation of Follicular Environment:

Zinc is thought to influence enzymes like 5α-reductase, which play a role in androgen-related hair loss. Thymulin may affect local immune signaling.

Potential Anagen Support:

Preclinical studies have indicated a possible ability to prolong the anagen (growth) phase of the hair cycle, though these findings are preliminary.

Anti-Inflammatory and Cell-Regulatory Activity:

Thymulin has been described in the literature as having immunomodulatory properties, which could potentially benefit inflammatory components of alopecia.

Support for Hair Follicle Integrity:

Animal studies have suggested improved follicular structure and signaling, but human relevance remains to be validated.

GHK-Cu Topical Spray⁴

The activity of GHK-Cu is thought to be multifaceted and includes:

Gene Modulation:

GHK-Cu has been associated with the upregulation of genes involved in tissue repair, anti-inflammatory signaling, and antioxidant defense, and the downregulation of genes linked to fibrosis and oxidative stress.

Skin Health Support:

Evidence suggests GHK-Cu may enhance dermal fibroblast function, collagen synthesis, and extracellular matrix remodeling—factors that contribute to skin firmness, elasticity, and texture.

Hair Follicle Environment:

GHK-Cu may modulate the follicular microenvironment through support of cell proliferation and anti-inflammatory effects. Preclinical studies have proposed its influence on hair follicle cycling and dermal papilla cell activity.

Adverse Reactions

Zinc-Thymulin^1-3

Common

Mild scalp irritation (redness, tingling, dryness)
Rare allergic or hypersensitivity reactions
No systemic effects have been documented in topical use at proposed concentrations

GHK-Cu Topical Spray⁴

Common

Mild local irritation
Sensitivity to other ingredients when combined in multi-agent products
Discoloration or staining

Contraindications & Precautions

Zinc Thymulin^1-3

Contraindications:

Known allergy or hypersensitivity to zinc, thymulin peptide, or any excipients
Active scalp infection, ulceration, or open lesions

Precautions:

Should not be used as a substitute for FDA-approved hair loss treatments unless advised by a healthcare provider
Not recommended for use near eyes or mucous membranes
Effects may vary significantly between individuals
Long-term safety has not been established in human studies

GHK-Cu Topical Spray⁴

Contraindications:

Hypersensitivity to GHK, copper peptides, or excipients
Active local infection, open wounds, or compromised skin barrier at site of application

Precautions:

Not studied in pregnancy or lactation
Avoid contact with mucous membranes and eyes
Inform patients of investigational status and variable efficacy
Long-term safety and pharmacokinetics in humans are not fully established

Storage

Storage: Refrigerate at 2°C–8°C (36°F–46°F)
Protect from light, heat, and moisture

References

Vickers, E. R. (2017). An analysis of the safety and efficacy of topical zinc-thymulin to treat androgenic alopecia. Hair Therapy and Transplantation, 7(1), Article No. 147. https://doi.org/10.4172/2167-0951.1000147
Lodish H, et al. (2008). Molecular Cell Biology, 6th ed. – Zinc signaling and peptide function.
Clinical Pharmacology [database online]. Zinc Monograph
Pickart L, Margolina A. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Int J Mol Sci. 2018;19(7):1987. doi:10.3390/ijms19071987 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073405/

Disclaimer

This sheet is a summary. It may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.