Valproic Acid Spray

Available Dosage Strengths

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Product Overview

Description

Valproic Acid Spray Description^1-4  

Valproic acid is an antiepileptic medication for treatment of partial and absence seizures. Although valproic acid is commonly used as an antiepileptic medication, there is data to support that valproic acid may facilitate hair growth in patients with androgenetic alopecia. The benefits of topical valproic acid on hair growth have been shown in an in vitro culture model, in a mice model, and in men with androgenetic alopecia in a randomized controlled trial. In the randomized controlled trial, valproic acid was shown to increase hair count in men with androgenetic alopecia.

Mechanism of Action

Mechanism of Action^1-4

The mechanism of how valproic acid stimulates hair growth is related to intracellular pathways and targets. Coordination of signaling between cells is important for formation and maintenance of the hair follicle. β-Catenin is critical for the development and growth of hair follicles through Wnt signaling. Without Wnt signals, β-catenin is phosphorylated by glycogen synthase kinase (GSK)-3 and then degraded. Inhibiting GSK-3 may enhance hair growth. Valproic acid may inhibit GSK-3 to facilitate hair growth.

Adverse Reactions

Common ⁴  

Mild itching, erythema

Contraindications & Precautions

Contraindications^1-4 

Hypersensitivity or intolerance to valproic acid or excipients
Active local infection, open wounds, or compromised skin barrier at site of application
In patients with known urea cycle disorder (UCD), such as ornithine transcarbamoylase deficiency
Not recommended during pregnancy

Precautions^1-4 

Avoid contact with mucous membranes and eyes

Storage

Store at 2°C–8°C (36°F–46°F). Protect from light, heat, and moisture.

References

Clinical Pharmacology valproic acid clinical monograph 2025 https://www.clinicalkey.com/pharmacology/
Choi SY, Kim HD, Kim BJ, Kim MN, Han DH. A case of androgenetic alopecia treated with valproic acid. Int J Dermatol. 2014 Mar;53(3):e214-5.
Jo SJ, Choi SJ, Yoon SY, Lee JY, Park WS, Park PJ, Kim KH, Eun HC, Kwon O. Valproic acid promotes human hair growth in in vitro culture model. J Dermatol Sci. 2013 Oct;72(1):16-24.
Jo SJ, Shin H, Park YW, Paik SH, Park WS, Jeong YS, Shin HJ, Kwon O. Topical valproic acid increases the hair count in male patients with androgenetic alopecia: a randomized, comparative, clinical feasibility study using phototrichogram analysis. J Dermatol. 2014 Apr;41(4):285-91.

Disclaimer

This information is for educational purposes only. This compounded product has not been reviewed, approved, or evaluated by the Food and Drug Administration for safety and effectiveness. This product is not intended to diagnose, treat, cure, or prevent any disease. No claims are made regarding treatment, cure, or prevention of any disease or condition.

This information may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.