Testosterone Cream

Available Dosage Strengths

40 mg/gm | 50 mg/gm | 100 mg/gm | 150 mg/gm | 200 mg/gm

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Disclaimer: Images are for reference only; actual products may vary.

Product Overview

Description

Description^1,2

Micronized testosterone (natural) is derived from plants, most commonly, yams. This starting material undergoes a synthetic process to bioidentical testosterone. Unlike injectable testosterone, free testosterone is metabolized rapidly after absorption, requiring more frequent administration opposed to the weekly-monthly injections (cypionate, enanthate etc…). It is used commonly to treat male hypogonadism that is due to low testosterone and improve libido in both men and women. Micronized testosterone is used for compounded dosage forms including transdermal creams.

Mechanism of Action

Mechanisms of Action^1-4

Testosterone binds to androgen receptors in various tissues, exerting anabolic and androgenic effects. These effects may include the development and maintenance of male secondary sexual characteristics, stimulation of muscle and bone growth, and regulation of libido and mood in both men and women.

Adverse Reactions

Adverse Reactions^1-4

Acne
Hypertension
Mood swings or irritability
Increased or decreased libido
Gynecomastia

Contraindications & Precautions

Contraindications & Precautions^1-4

Contraindications:

Known hypersensitivity to testosterone
Males with carcinoma of the breast or known or suspected carcinoma of the prostate
Pregnant or breastfeeding women
Patients with serious cardiac, hepatic, or renal disease

Precautions:

Monitor hematocrit and hemoglobin levels.
Regularly assess liver function tests.
Evaluate lipid profiles periodically.
Monitor for signs of sleep apnea.
Use cautiously in patients with a history of cardiovascular disease.
Wear gloves with topical preparations (creams/gels) and wash hands thoroughly after each application.

Storage

Storage^1,3

Store micronized testosterone at room temperature 20°C to 25°C (68°F to 77°F) (unless otherwise specified, i.e gel troches are refrigerated) in a dry place, away from heat and light. Do not freeze. Keep out of reach of children.

References

Clinical Pharmacology Testosterone clinical monograph accessed June 17 2025 ; https://www.clinicalkey.com/pharmacology/monograph/595?n=Testosterone
Tauchen J, Jurášek M, Huml L, Rimpelová S. Medicinal Use of Testosterone and Related Steroids Revisited. Molecules. 2021 Feb 15;26(4):1032. doi: 10.3390/molecules26041032. PMID: 33672087; PMCID: PMC7919692.
AndroGel (testosterone gel 1.62% for topical use) [package insert] AbbVie US LLC , revised May 2013, accessed June 2025 through: https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021015s036lbl.pdf https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/085635s040lbl.pdf
Clayton AH, Goldstein I, Kim NN, Althof SE, Faubion SS, Faught BM, Parish SJ, Simon JA, Vignozzi L, Christiansen K, Davis SR, Freedman MA, Kingsberg SA, Kirana PS, Larkin L, McCabe M, Sadovsky R. The International Society for the Study of Women’s Sexual Health Process of Care for Management of Hypoactive Sexual Desire Disorder in Women. Mayo Clin Proc. 2018 Apr;93(4):467-487. doi: 10.1016/j.mayocp.2017.11.002. Epub 2018 Mar 12. PMID: 29545008.

Disclaimer

This sheet is a summary. It may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.