(EDaily Plus+)
Available Dosage Strengths
6 mg / 50 mg / 2 mg / 1 mg / 25 mg / 2 mg
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Tadalafil Description1-3
Tadalafil, a phosphodiesterase type 5 (PDE5) inhibitor, has a mean terminal half-life of over 17 hours. This half-life is much longer than other PDE-5 inhibitors. This half-life allows for once-daily or on-demand dosing. The drug is indicated for the treatment of pulmonary arterial hypertension (PAH), erectile dysfunction (ED), benign prostatic hypertrophy (BPH), or the concurrent treatment of ED and BPH.
Citrulline Description4
Citrulline (known commonly as watermelon) is an amino acid. It is converted in the body into arginosuccinate and then subsequently arginine. Your kidneys change citrulline into arginine and nitric oxide. Nitric oxide may provide several functions in the body including vasodilation of blood vessels, immune function protection and regulation of glucose and fatty acids in the body. Because citrulline may be converted into nitric oxide, it has been studied for its ability to promote erectile dysfunction.
Vitamin B65
Vitamin B6, a water-soluble vitamin, is important for functioning of neurotransmitter in the body, brain health, immune function and metabolic activity in the body.
Vitamin B126
Cyanocobalamin, the synthetic compound of vitamin B12, supports several methylation reactions in the body. It is essential for growth, cell reproduction, hematopoiesis, and nucleoprotein and myelin synthesis. It is important for red blood cell production and for the activity of cells that rapidly divide in the body (epithelial cells, bone marrow, myeloid cells).
Zinc7
Zinc, an essential trace element, is critical for many biological functions in the body including appetite, testicular maturation, immune function and wound healing.
Apomorphine8,9
Apomorphine is a central dopamine agonist. It has been studied through randomized controlled trials for its use for erectile dysfunction. The most common formulation that has been studied is through administration of the drug sublingually. The drug has a half-life of 2 to 3 hours and is recommended to be taken approximately 20 minutes prior to sexual activity.
Tadalafil1-3
Phosphodiesterase (PDE) has many isoforms and is an enzyme that has many functions in the body including degrading the effect of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). PDE5 is an enzyme that is found in many parts of the body including in the smooth muscle of the corpus cavernosum, prostate, bladder, the vascular and visceral smooth muscle, skeletal muscle, urethra, platelets, kidney, lung, cerebellum, heart, liver, testis, seminal vesicle, and pancreas. Tadalafil is a selective inhibitor of PDE5, the enzyme responsible for the degradation of cGMP. The drug has selective activity on PDE5 than other phosphodiesterase isoforms. Tadalafil activity on PDE5 is more than 10,000-fold more than for PDE1, PDE2, PDE4, and PDE7 enzymes. Increased cGMP leads to smooth muscle relaxation in the corpus cavernosum which can help in maintaining a penile erection.
Citrulline4
Citrulline may inhibit the activity of PDE5 in the body by increasing arginine availability, stimulating production of nitric oxide and preventing degradation of cGMP. This activity may increase the ability to gain and maintain a penile erection through muscle relaxation.
Vitamin B65
Vitamin B6 is made up of at least three main compounds: pyridoxine, pyridoxal, and pyridoxamine. Pyridoxine works in the red blood cells to be activated. Pyridoxamine acts as a coenzyme while pyridoxamine is converted into pyridoxamine phosphate. These active forms act as coenzymes for at least 60 metabolic processes including the metabolism of fat, protein, and carbohydrate.
Vitamin B126
Vitamin B12 is important for division and growth of the cell. It is converted to coenzyme B12 in the body and in this form facilitates the conversion of homocysteine to methionine (methylcobalamin) and plays an important role in converting methylmalonyl-coenzyme A to succinyl-Co-A (fatty acid and amino acid metabolism). Without coenzyme B12, tetrahydrofolate cannot be produced from 5-methyl tetrahydrofolate leading to folate deficiency. In addition, vitamin B12 is needed to produce myelin and is important for axon and nerve development. Gastrointestinal absorption of vitamin B12 depends on the presence of sufficient intrinsic factor and calcium ions.
Zinc7
Zinc is important for enzymatic activity in the body involving carbohydrates, lipids, proteins, and nucleic acids. It may provide support for immune function, wound healing and development of testicular activity.
Apomorphine8,9
Apomorphine works on D2 receptors in central dopaminergic areas of the brain (paraventricular nucleus and the medial preoptic of the hypothalamus) to stimulate an erection. It may also target dopamine D1-like receptors and increase nitric oxide in the corpus cavernosum.
Tadalafil1
Common
Vitamin B65
Common
Vitamin B126
Common
Zinc salts7
Common
Apomorphine8,9
Common
Contraindications1,2,8,9
Precautions1,2,8,9
Store at 20°C to 25°C (68°F to 77°F). Protect from light, moisture, and heat.
This information is for educational purposes only. This compounded product has not been reviewed, approved, or evaluated by the Food and Drug Administration for safety and effectiveness. This product is not intended to diagnose, treat, cure, or prevent any disease. No claims are made regarding treatment, cure, or prevention of any disease or condition.
This information may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.
