Available Dosage Strengths
2% / 3%
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This topical gel formulation contains sildenafil and arginine. The formulation may be used to enhance genital blood flow in people that are experiencing erectile dysfunction or female sexual arousal disorder.1-7
Sildenafil1-5
Sildenafil, a phosphodiesterase type 5 (PDE5) inhibitor, has a half-life of 4 hours. Clinically, the drug is used to treat erectile dysfunction and pulmonary hypertension. Studies have shown it may also be beneficial for female sexual arousal disorder. Orally, because of the half-life, the drug is used “on-demand” prior to sexual activity.
Arginine6,7
L-Arginine, an essential amino acid, is converted to nitric oxide. It is naturally found in red meat, poultry, fish, and dairy. Nitric oxide has been found to be a powerful vasodilator and neurotransmitter. Arginine supports protein synthesis, immune function and wound healing.
Sildenafil1-4
Phosphodiesterase (PDE) has many isoforms and is an enzyme that has many functions in the body including degrading the effect of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). PDE5 is an enzyme that is found in many parts of the body including in the smooth muscle of the corpus cavernosum, prostate, bladder, the vascular and visceral smooth muscle, skeletal muscle, urethra, platelets, kidney, lung, cerebellum, heart, liver, testis, seminal vesicle, and pancreas. Sildenafil is structurally similar to cGMP and prevents degradation of cGMP by competitively binding and inhibiting activity of PDE5. When PDE5 is inhibited, cGMP accumulates and leads to smooth muscle relaxation. Studies have shown that sildenafil facilitates the relaxation of the clitoral corpus cavernosum through the nitric oxide-cGMP pathway. This may improve genital blood flow and vaginal engorgement.
Arginine6,7
L-Arginine is necessary for making proteins and is commonly used to promote circulation. The body converts arginine to nitric oxide (NO) through the action of nitric oxide synthase which may relax blood vessels, allowing more blood to flow.1
Common (topically)1-7
Oral (sildenafil)
Contraindications: 1-7
Precautions:
Store at 20–25°C (68–77°F). Protect from excessive heat, light, and moisture.
This information is for educational purposes only. This compounded product has not been reviewed, approved, or evaluated by the Food and Drug Administration for safety and effectiveness. This product is not intended to diagnose, treat, cure, or prevent any disease. No claims are made regarding treatment, cure, or prevention of any disease or condition.
This information may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.
