Plampasil-D
Available Dosage Strengths
2% / 2% / 1% / 2% / 5% / 5,000 u/gm
Want to Prescribe?
This gel combines ingredients that may promote wound healing, decrease pain, and prevent infection. The goal of this combination is to regenerate tissue and enhance circulation around chronic and acute wounds.
Phenytoin1-4
Phenytoin has been used since 1937 as an anti-epileptic medication and through its use as an anti-epileptic drug it was discovered that it has an adverse effect of gingival hyperplasia. This stimulated its interest in its ability to heal wounds. It has been studied for diabetic ulcers, decubitus ulcers, venous stasis ulcers, and traumatic wounds.
Lidocaine5-7
Lidocaine is an amide-type topical anesthetic. It is effective and safe for topical pain treatment of many different pain conditions (lower back pain, peripheral neuropathy, joint pain).
Arginine8-10
Arginine is a semi-essential amino acid. Arginine increases vasodilation of blood vessels, decreases inflammation, improves immune function and collagen development at the site of the wound. These activities may facilitate improved wound healing.
Metronidazole11-13
Metronidazole is an antibacterial that has good activity against anaerobic infections which is common in individuals with wound infections. It may also be effective against both gram positive and negative aerobic bacteria. Metronidazole can facilitate a reduction of wound odors, wound exudate, pain and cellulitis that surround the wound. Generally, the antibiotic helps improve the appearance of the wound.
Pentoxifylline14-16
Pentoxifylline may have anti-inflammatory effects and inhibit fibroblast activity. It also improves blood circulation to facilitate oxygen delivery to tissues which is important for wound healing.
Vitamin D17-20
Vitamin D, a fat soluble, vitamin, was discovered in the early 1920s. It is available in two main types D2, ergocalciferol, and D3, cholecalciferol. It is an essential vitamin that supports bone health, enhances immune function, and helps to regulate calcium and phosphorous levels. Vitamin D, which is inert in the body, can be obtained from sun exposure, foods and supplements and must be activated in the body to have a physiological effect. It may have immunomodulatory, anti-inflammatory activity, and antioxidant activity for the skin.
Phenytoin1-4
Phenytoin has several potential ways it may help heal wounds. It may increase the expression of platelet-derived growth factor B in macrophages. It may also stimulate an increase in fibroblast activity to provide formation of granulation tissue and facilitate collagen formation. competitive glucocorticoid antagonism, pain alleviation by membrane-stabilizing action, and antibacterial activity.
Lidocaine5-7
Lidocaine stabilizes nerves by preventing ion increases that are needed for the initiation and propagation of electrical impulses. It decreases pain by nerve conduction blockade by diminishing nerve membrane permeability to sodium. This activity inhibits membrane depolarization and affects ability of the nerve to stimulate electrical activity.
Arginine8-10
Arginine is a precursor to the formation of nitric oxide. Nitric oxide helps vasodilate blood vessels to facilitate blood flow, oxygen and nutrients to the site of the wound. This activity may facilitate improved wound healing. It may also stimulate collagen formation, increase growth hormone and insulin-like growth factor, and support T cell activity to help prevent infection at the site of a wound.
Metronidazole11-13
Metronidazole has an attraction for anerobic bacteria where it is transported intracellularly to interact with DNA leading to inhibition of DNA synthesis and DNA degradation.
Pentoxifylline14-16
Pentoxifylline may facilitate through its vasodilator activities increased flow of blood to improve oxygen delivery. It may also have anti-inflammatory activity by decreasing synthesis of inflammatory mediators including decreasing cytokine release and decreasing white blood cell activity. It may also decrease oxygen-free radical production to reduce oxidative stress.
Vitamin D17-20
Vitamin D may regulate keratinocytes to stimulate epithelialization to facilitate wound healing. It also may may aid in healing of wounds by decreasing inflammation in the skin through a decrease in pro-inflammatory mediators such as IL-6 and TNF-a. It also promotes angiogenesis through factors such as vascular endothelial growth factor (VEGF) and platelet derived growth factor (PDGF) which help with nutrient and oxygen delivery to the site of the wound.
Common1
Contraindications 1,2
Precautions1,2
Store at 20°C to 25°C (68°F to 77°F). Protect from light, moisture, and heat.
This information is for educational purposes only. This compounded product has not been reviewed, approved, or evaluated by the Food and Drug Administration for safety and effectiveness. This product is not intended to diagnose, treat, cure, or prevent any disease. No claims are made regarding treatment, cure, or prevention of any disease or condition.
This information may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.
