Available Dosage Strengths
1 mg/mL
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Phenylephrine HCI 0.1% Injection Description1-4
Phenylephrine is an alpha-1 adrenergic receptor agonist used in various clinical settings to induce vasoconstriction. In the management of prolonged erection greater than 4 hours (priapism), phenylephrine 0.1% (1 mg/mL) solution is administered via intracavernous injection to achieve detumescence by contracting smooth muscle in the corpora cavernosa and reducing blood flow.
Mechanism of Action1-4
Phenylephrine acts as a selective alpha-1 adrenergic receptor agonist. When injected directly into the corpus cavernosum, it causes vasoconstriction of the cavernous arterial smooth muscle, leading to decreased arterial inflow and increased venous outflow. This action facilitates resolution of the prolonged erection that can be induced from oral or intracavernousal medications used for the treatment of erectile dysfunction (sildenafil, tadalafil, alprostadil, phentolamine, papaverine, vardenafil etc..)
Adverse Reactions1-4
Common
Local:
– Pain at the injection site
– Penile fibrosis (scarring)
– Hematoma or ecchymosis
Systemic (especially with higher doses or improper administration):
– Hypertension
– Reflex bradycardia
– Arrhythmias
– Headache
– Anxiety or nervousness
Contraindications & Precautions1-4
Contraindications:
– Known hypersensitivity to phenylephrine or any component of the formulation
– Severe hypertension or cardiovascular disease (relative contraindication)
Precautions:
– Monitor blood pressure and heart rate during and after administration
– Use the lowest effective dose and shortest duration to minimize systemic effects
– Avoid in patients with significant cardiovascular comorbidities unless necessary and under close supervision
-Use caution in renally impaired patients
20°C to 25°C (68°F to 77°F) in a dry place, away from heat and light. Do not refrigerate. Do not freeze. Keep out of reach of children.
This sheet is a summary. It may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.
