Available Dosage Strengths
4% / 1% / 0.3% / 0.01%
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This topical gel combines four active ingredients —Niacinamide, Panthenol, Estriol, and Tretinoin—to target multiple signs of skin aging, photodamage, and barrier dysfunction. It is used primarily in cosmetic dermatology to improve skin texture, tone, elasticity, and hydration, while also promoting cell turnover and collagen remodeling.1-9
Niacinamide – (Vitamin B3) A water-soluble vitamin that may strengthen the skin barrier, reduce inflammation, and improve uneven pigmentation and fine lines supporting healthy skin.1-3
Panthenol – (Precursor to vitamin B5) A humectant and emollient with potential for anti-inflammatory and skin-soothing properties; may support wound healing and hydration.4-5
Estriol – A weak estrogen with potential for skin-rejuvenating properties; used in postmenopausal women or estrogen-deficient states to restore dermal thickness and elasticity.6-7
Tretinoin – Vitamin A derivative and potent retinoid that stimulates skin cell turnover, may help smooth wrinkles, and may help to treat hyperpigmentation and acne.8-9
Niacinamide1-3
Panthenol 4,5
Estriol 6,7
Tretinoin8,9
Niacinamide 1-3: – Mild flushing, tingling, rare allergic contact dermatitis
Panthenol 4,5: – Occasional mild irritation in sensitive individuals
Estriol 6,7: – Local irritation, breast tenderness, spotting (rare); systemic absorption is low but possible; *Cumulative estrogenic side effects are rare but possible with long-term estriol use.
Tretinoin 8,9: – Peeling, dryness, redness, burning, initial acne flare; photosensitivity is common
Niacinamide 1-3: – Contraindication: Hypersensitivity – Precaution: Use cautiously in rosacea or sensitive skin
Panthenol 4,5: – Contraindication: Allergy to panthenol – Precaution: Rare allergic reactions
Estriol 6,7: – Contraindication: Estrogen-dependent cancers, thromboembolic history, unexplained bleeding – Precaution: Avoid in pregnancy/lactation; use under medical supervision
Tretinoin 8,9: – Contraindication: Pregnancy, hypersensitivity, irritated or sunburned skin – Precaution: Use sunscreen; discontinue with severe irritation.
Store at 20°C to 25°C (68°F to 77°F) in a dry place, away from heat and light. Keep out of reach of children.
This information is for educational purposes only. This compounded product has not been reviewed, approved, or evaluated by the Food and Drug Administration for safety and effectiveness. This product is not intended to diagnose, treat, cure, or prevent any disease. No claims are made regarding treatment, cure, or prevention of any disease or condition.
This information may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.
