Available Dosage Strengths
4% / 1% / 0.3% / 0.01%
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This topical gel combines four active ingredients—Niacinamide, Panthenol, Estriol, and Tretinoin—to target multiple signs of skin aging, photodamage, and barrier dysfunction. It is used primarily in cosmetic dermatology to improve skin texture, tone, elasticity, and hydration, while also promoting cell turnover and collagen remodeling.
Niacinamide – (Vitamin B3) A water-soluble vitamin that may strengthen the skin barrier, reduce inflammation, and improve uneven pigmentation and fine lines supporting healthy skin.
Panthenol – (Precursor to vitamin B5) A humectant and emollient with potential for anti-inflammatory and skin-soothing properties; may support wound healing and hydration.
Estriol – A weak estrogen with potential for skin-rejuvenating properties; used in postmenopausal women or estrogen-deficient states to restore dermal thickness and elasticity.
Tretinoin – Vitamin A derivative and potent retinoid that stimulates skin cell turnover, may help smooth wrinkles, and may help to treat hyperpigmentation and acne.
Niacinamide1-3:
– Inhibits melanosome transfer which may assist in pigmentation
– Stimulates ceramide production which may strengthen the skin barrier
– Reduces local inflammation which may calm erythema and acne
– May enhance dermal fibroblast activity which may promote elasticity
Panthenol 4,5:
– Converted to pantothenic acid (Vitamin B5) in the skin
– Pantothenic acid can improve skin hydration via humectant properties
– Promotes fibroblast proliferation and keratinocyte differentiation
– Anti-inflammatory effects aid in healing irritated or sensitive skin
Estriol 6,7:
– Binds estrogen receptors in dermis and epidermis potentially leading to:
– Increases in collagen types I and III
– Enhanced vascularity and hydration
– Thickening of dermal-epidermal junction, potentially improving firmness
Tretinoin8,9:
– Binds retinoic acid receptors (RARs) which modulate gene expression that may influence directly or indirectly:
– Accelerated keratinocyte turnover
– Stimulation of fibroblasts to produce collagen and elastin
Niacinamide 1-3: – Mild flushing, tingling, rare allergic contact dermatitis
Panthenol 4,5: – Occasional mild irritation in sensitive individuals
Estriol 6,7: – Local irritation, breast tenderness, spotting (rare); systemic absorption is low but possible; *Cumulative estrogenic side effects are rare but possible with long-term estriol use.
Tretinoin 8,9: – Peeling, dryness, redness, burning, initial acne flare; photosensitivity is common
Niacinamide 1-3: – Contraindication: Hypersensitivity – Precaution: Use cautiously in rosacea or sensitive skin
Panthenol 4,5: – Contraindication: Allergy to panthenol – Precaution: Rare allergic reactions
Estriol 6,7: – Contraindication: Estrogen-dependent cancers, thromboembolic history, unexplained bleeding – Precaution: Avoid in pregnancy/lactation; use under medical supervision
Tretinoin 8,9: – Contraindication: Pregnancy, hypersensitivity, irritated or sunburned skin – Precaution: Use sunscreen; discontinue with severe irritation.
Store at 20°C to 25°C (68°F to 77°F) in a dry place, away from heat and light. Keep out of reach of children.
This sheet is a summary. It may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.
