Available Dosage Strengths
5% / 0.1%
Want to Prescribe?
This is a compounded skincare formulation prepared with niacinamide and tretinoin to support healthy looking skin. The ingredients are commonly selected for appearance-related skin concerns, including those involving complexion and texture.
Niacinamide1-3
Niacinamide, a form of vitamin B3, is a water-soluble vitamin that is essential for cellular metabolism. Niacin and niacinamide are both forms of vitamin B3 but have slight structural differences. It has been shown to support the skin barrier, act as an anti-inflammatory, antioxidant and skin-brightening agent. Topically, niacinamide has been shown to be helpful for acne vulgaris, melasma, psoriasis and aging skin.
Adapalene4-6
Adapalene is a third-generation retinoid. It has been used for many skin conditions including acne vulgaris, photoaging, melasma, and hyperpigmentation skin disorders. It has anti-inflammatory and comedolytic activity.
Niacinamide1-3
Niacinamide has various mechanisms of activity to support skin health. Niacinamide is a precursor to the NAD(P) family of coenzymes. These coenzymes are important for metabolic activity in the skin. The reduced form, NAD(P)H, has antioxidant activity and works to neutralize free radicals. Niacinamide provides anti-inflammatory activity and decreases sebum excretion. It has been shown to improve acne vulgaris by affecting neutrophil chemotaxis and suppresses cytokine-mediated induction of nitric oxide synthase. In addition, niacinamide may prevent photoimmunosuppression and photocarcinogenesis, prevent loss of collagen in the dermal layer of skin, and improve the barrier function of the skin. Niacinamide may help with skin lines and wrinkles 1) by increasing collagen production or 2) by reducing the amount of dermal glycosaminoglycans that are seen with photodamaged or wrinkled skin. Niacinamide supports the barrier function of the skin by increasing the lipid and protein stratum corneum. This increase in lipid and protein decreases the trans-epidermal water loss and provides resistance to skin damage from damaging agents. Niacinamide also is thought to inhibit the transfer of melanin from the melanocytes to keratinocytes to decrease hyperpigmentation of skin.
Adapalene4-6
Adapalene binds to retinoic acid receptors and inhibits cell proliferation. It targets keratinization, inflammation, and the differentiation of follicular epithelial cells. It also accelerates the turnover of dead skin cells.
Niacinamide1-3,7
Common
Tretinoin4-6
Common
Contraindications1-7
Precautions1-7
Store at 20–25°C (68–77°F), in a cool, dry place, away from heat and direct sunlight. Do not freeze. Keep container tightly closed and out of reach of children .
This information is for educational purposes only. This compounded product has not been reviewed, approved, or evaluated by the Food and Drug Administration for safety and effectiveness. This product is not intended to diagnose, treat, cure, or prevent any disease. No claims are made regarding treatment, cure, or prevention of any disease or condition.
This information may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.
