NAD+ Nasal Spray

Available Dosage Strengths

150 mg/mL

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Disclaimer: Images are for reference only; actual products may vary.

Product Overview

Description

NAD+ Nasal Spray Description^1-6

Nicotinamide Adenine Dinucleotide (NAD⁺) is crucial for metabolic activity (needed in over 500 enzymatic processes) in the body and in maintaining health. NAD+ is critical in energy metabolism, homeostasis in mitochondria and in cellular survival or death. In addition, NAD+ is a mediator of cellular functions including maintenance and repair of DNA. As people age, NAD+ levels decrease. Restoring NAD+ levels can improve altered metabolism, decrease disease susceptibility, and promote longevity.

The potential benefits of increasing NAD+ levels include:

Improved brain functioning

Brain protection from neurodegeneration

Improved blood vessel vascularization

Reduced hepatic steatosis

Improved muscle strength and pancreas functioning (increased insulin secretion)

Reduced inflammation

Mechanisms of Action

Mechanism of Action^1-6

NAD+ is critical for metabolism and physiological function. It accepts electrons during metabolic reactions to become NADH (reduced form). NADH uses the electron to donate ot other molecules. This is important for ATP production in the body. This proces occurs during glycolysis, fatty acid oxidation, and the TCA cycle. There is a continuous conversion of NAD+ to NADH in cells in the body which is critical for energy flow. NAD+ is also important for sirtuin regulation (DNA repair, inflammation processes, and fat metabolism). It is a substrate for PARPs (poly (ADP-ribose) polymerases) (repair of damaged DNA), is important to prevent neurodegenerative processes.

Adverse Reactions

Adverse Reactions^2,6

Common

Flushing, warm sensation

Headache, dizziness, lightheadedness

Nausea, abdominal cramping

Contraindications & Precautions

Contraindications & Precautions^2,6

Contraindications

Known hypersensitivity to NAD+ or any component of the solution

Active infection or inflammation

Precautions

Patients should be monitored during and after administration for tolerance

Storage

Store at 2°C to 8°C (36°F to 46°F); Protect from light, heat, and moisture.

References

https://www.nad.com/what-is-nad
Hwang ES, Song SB. Possible Adverse Effects of High-Dose Nicotinamide: Mechanisms and Safety Assessment. Biomolecules. 2020 Apr 29;10(5):687.
Covarrubias AJ, Perrone R, Grozio A, Verdin E. NAD⁺ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol. 2021 Feb;22(2):119-141.
Xie N, Zhang L, Gao W, Huang C, Huber PE, Zhou X, Li C, Shen G, Zou B. NAD⁺ metabolism: pathophysiologic mechanisms and therapeutic potential. Signal Transduct Target Ther. 2020 Oct 7;5(1):227.
Mark, J. The Vital Role of NAD in Cellular Metabolism and Aging https://www.therealgutdoctor.com/the-vital-role-of-nad-in-cellular-metabolism-and-aging/. August 13, 2024. Accessed June 29, 2025
Lopez J NAD IV Therapy Side Effects: Exploring the Potential Risks. https://www.azivmedics.com/side-effects-of-nad-therapy July 6, 2023. Accessed June 30, 2025.

Disclaimer

This sheet is a summary. It may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.