Gonadorelin Injection

Available Dosage Strengths

1 mg Vial | 2 mg Vial

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Disclaimer: Images are for reference only; actual products may vary.

Product Overview

Description

Gonadorelin Injection Description^1-5

Gonadorelin is a synthetic decapeptide that has the same amino acid sequence as the naturally produced gonadotropin-releasing hormone (GnRH). Both compounds are made up of 10 amino acids arranged in a specific sequence: pyro-Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂.

Clinically, it is used as a diagnostic agent after pituitary surgery. In males FSH and LH stimulate testosterone production and sperm production. In females, FSH and LH regulate the menstrual cycle and ovulation. The half-life of gonadorelin ranges from 2 to 40 minutes.

Mechanism of Action

Mechanism of Action^1-5

GnRH is made in the hypothalamus and functions to stimulate the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. This increase in FSH and LH may stimulate the production and release of testosterone by the male testes and estrogen by the female ovaries and placenta.

Adverse Reactions

Common^1-5

Headache
Nausea
Abdominal discomfort
Flushing
Dizziness or lightheadedness
Injection site reactions such as redness, pain, or swelling

Contraindications & Precautions

Contraindications^1,2,4

Intolerance or hypersensitivity to gonadorelin
Use in pregnant or breastfeeding women is contraindicated

Precautions^1,2,4

Rare instances of hypersensitivity reaction (bronchospasm, tachycardia, flushing, urticaria, induration at injection site) and anaphylactic reactions have been reported following multiple-dose administration.
There has been a report of pituitary apoplexy and sudden blindness following gonadotropin-releasing hormone administration to a patient with a gonadotropin-secreting adenoma.

Storage

Store refrigerated at 36°F to 46°F (2°C – 8°C). Discard 28 days after mixing. Do not freeze. Keep out of reach of children and pets.

References

DrugBank. Gonadorelin: Uses, Interactions, Mechanism of Action.
https://go.drugbank.com/drugs/DB00644
RxList. Factrel (Gonadorelin): Side Effects, Uses, Dosage https://www.rxlist.com/factrel-drug.htm#description. August 8, 2022
Medicines.org.uk. Gonadorelin 100 mcg Powder for Solution for Injection – SmPC.
https://www.medicines.org.uk/emc/product/4853/smpc
DailyMed. GONABREED – Gonadorelin Injection, Solution.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9bc44a48-ff45-468a-a60d-c490a667
Gonadorelin’s Potential Interactions With The Hypothalamic-Pituitary-Gonadal Axis https://www.corepeptides.com/gonadorelins-potential-interactions-with-the-hypothalamic-pituitary-gonadal-axis/ June 7, 2025 Accessed July 14, 2025

Disclaimer

This information is for educational purposes only. This compounded product has not been reviewed, approved, or evaluated by the Food and Drug Administration for safety and effectiveness. This product is not intended to diagnose, treat, cure, or prevent any disease. No claims are made regarding treatment, cure, or prevention of any disease or condition.

This information may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.