GHK-Cu Facial Cream

Available Dosage Strengths

0.5% | 2.55%

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Product Overview

Description

GHK-Cu is a naturally occurring copper-binding peptide that plays a role in tissue remodeling and repair. It is composed of a tripeptide (glycine–histidine–lysine) complexed with copper (II). Endogenously present in human plasma, its levels decline with age.

Topical formulations of GHK-Cu are being used for their potential to support skin regeneration, improve skin appearance, and promote scalp health. There is some evidence that the peptide may also influence hair follicle growth.¹

Mechanism of Action

The activity of GHK-Cu is thought to be multifaceted and includes:

Gene Modulation:

GHK-Cu has been associated with the upregulation of genes involved in tissue repair, anti-inflammatory signaling, and antioxidant defense, and the downregulation of genes linked to fibrosis and oxidative stress.¹

Skin Health Support:

Evidence suggests GHK-Cu may enhance dermal fibroblast function, collagen synthesis, and extracellular matrix remodeling—factors that contribute to skin firmness, elasticity, and texture.¹

Hair Follicle Environment:

GHK-Cu may modulate the follicular microenvironment through support of cell proliferation and anti-inflammatory effects. Preclinical studies have proposed its influence on hair follicle cycling and dermal papilla cell activity.¹

Adverse Reactions

Common¹

Mild local irritation
Sensitivity to other ingredients when combined in multi-agent products
Discoloration or staining

Contraindications & Precautions

Contraindications:

Hypersensitivity to GHK, copper peptides, or excipients
Active local infection, open wounds, or compromised skin barrier at site of application

Precautions:

Not studied in pregnancy or lactation
Avoid contact with mucous membranes and eyes
Inform patients of investigational status and variable efficacy
Long-term safety and pharmacokinetics in humans are not fully established

Storage

Store at 2°C–8°C (36°F–46°F)
Protect from light, heat, and moisture

References

Pickart L, Margolina A. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Int J Mol Sci. 2018;19(7):1987. doi:10.3390/ijms19071987 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073405/

Disclaimer

This sheet is a summary. It may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.