DHEA-7-Keto SR K100M Capsules

Available Dosage Strengths

100 mg

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Product Overview

Description

7-Keto-DHEA is a naturally occurring metabolite of dehydroepiandrosterone (DHEA). Unlike DHEA, it cannot be converted into sex hormones such as testosterone or estradiol. There is some evidence of effectiveness in the following areas: weight loss, metabolic support, improved immune function, and cognitive enhancement. [1,2,3,4]

Mechanism of Action

7-Keto-DHEA is believed to enhance thermogenesis (heat production) and basal metabolic rate by modulating the activity of 3 key metabolic enzymes, including: Glycerol-3-phosphate dehydrogenase, cytosolic malic enzyme, citrate lyase.

These enzymes influence fatty acid oxidation and mitochondrial efficiency, contributing to increased energy expenditure by cells. [1,2]

Adverse Reactions

Headache.
Nausea or gastrointestinal upset.
Mild dizziness.
Irritability.
Sleep disturbances (less common).
Because it does not convert into sex hormones, androgenic side effects (e.g., acne, hair loss, hirsutism) are rare or absent. [1,2]

Contraindications & Precautions

Contraindications:

Hypersensitivity to 7-keto-DHEA or any excipients in the product.
Pregnancy or breastfeeding (insufficient safety data).

Precautions:

Use caution in individuals with autoimmune diseases due to theoretical immune-enhancing effects.
May interfere with thyroid function tests (e.g., T3/T4 levels); however, clinical significance is unclear.
People with hormone-sensitive conditions may still want to consult a healthcare provider, even though 7-keto-DHEA lacks direct hormonal activity.
Safety in children and adolescents has not been established. [1,2]

Storage

Store in a cool, dry place, away from direct light and heat; Room temperature (20°C–25°C / 68°F–77°F) is ideal.

References

7-Keto DHEA – Patient Handout; NatMed Pro; 2025; https://naturalmedicines-therapeuticresearch-com.lp.hscl.ufl.edu/databases/food,-herbs-supplements/patienthandout.aspx?productid=835&lang=en
7-Keto DHEA – Professional Monograph; NatMed Pro; 2025; https://naturalmedicines-therapeuticresearch-com.lp.hscl.ufl.edu/databases/food,-herbs-supplements/professional.aspx?productid=835
Douglas S. Kaiman, Carlon M. Colker, Melissa A. Swain, Georgeann C. Torina, Qiuhu Shi. A randomized, double-blind, placebo-controlled study of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy overweight adults. Current Therapeutic Research. Volume 61, Issue 7, 2000, 435-442.
Jeyaprakash N, Maeder S, Janka H, Stute P. A systematic review of the impact of 7-keto-DHEA on body weight. Arch Gynecol Obstet. 2023 Sep;308(3):777-785.

Disclaimer

This information is for educational purposes only. This compounded product has not been reviewed, approved, or evaluated by the Food and Drug Administration for safety and effectiveness. This product is not intended to diagnose, treat, cure, or prevent any disease. No claims are made regarding treatment, cure, or prevention of any disease or condition.

This information may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.