Available Dosage Strengths
100 mg / 100 mg / 12 mg
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The combination of theanine, magnesium and melatonin may facilitate relaxation, decrease stress and facilitate better sleep.
Theanine1-4
Theanine, a non-protein amino acid, was discovered in green tea in 1949. It can be also found in other teas including black and white tea and certain mushrooms. Theanine has structural similarity to the neurotransmitters glutamine and gamma aminobutyric acid (GABA). It shares the ability of these to cross the blood brain barrier. It has a caramel flavor and helps to alleviate the bitter taste of caffeine. In addition, it is thought to have many pharmacological properties including the following: antioxidant, anti-inflammatory, neuroprotective, anti-cancer, anti-anxiety, metabolic, heart, liver and kidney protective, and immune effects.
Magnesium5-7
Magnesium, the second most abundant intracellular cation, is a cofactor in numerous enzymatic reactions in the body. The electrolyte facilitates energy metabolism and protein and nucleic acid synthesis. Magnesium is thought to relax smooth muscles, and it is critical when replacing low potassium and calcium levels, treats eclampsia, helps to relieve constipation, manage arrhythmias, and help with relaxation of bronchial smooth muscle for asthma patients. It also may help to improve mood and improve sleep quality.
Melatonin8-10
Melatonin, a neurohormone, has been used to regulate circadian rhythm. Melatonin has been used in jet lag and sleep disorders, irregular sleep-wake disorders, shift-work disorders and non-24-hour sleep disorders in adults.
Theanine1-4
Theanine activity supports many different mechanisms of activity. As an antioxidant, theanine decreases reactive oxygen species development and increases the activity of antioxidant enzymes to decrease oxidative damage. As an anti-inflammatory, theanine decreases proinflammatory factors, including cyclooxygenase-2, prostaglandin E2, nitric oxide synthase, and nitric oxide. Theanine has been shown to be neuroprotective stimulating the release of glutathione. In addition, theanine has been shown to have a relaxing effect and help induce sleep and sleep duration. It increases GABA, serotonin, and dopamine to affect mood regulation. Thus, there is evidence to show that it has a role in helping depression and stress, as well as emotional and cognitive function. Theanine has been shown to increase cancer cell apoptosis and decrease cancer cell growth, decrease liver cirrhosis, decrease nephrotoxicity, and decrease vascular remodeling.
Magnesium5-7
Magnesium is a cofactor in ATP-dependent sodium-potassium pumps found in muscle membranes. Correction of low potassium often requires replacement of not only the potassium but also magnesium. Magnesium is also used to decrease calcium uptake and decrease potassium efflux in cardiac cells.
For asthma, magnesium decreases the uptake of calcium by smooth muscle in the lung. It may also decrease mast cell degranulation which will decrease inflammatory mediators. Magnesium also increases nitric oxide and prostacyclin synthesis, which may decrease asthma severity.
For sleep, magnesium may help with neurotransmitter regulation by helping balance of the amounts of GABA and glutamate, modulate cortisol, support melatonin synthesis and help with muscle relaxation and nervous system support.
Melatonin8-10
Melatonin production is generated from the conversion of tryptophan. Tryptophan is converted to serotonin and then subsequently to melatonin. The neurohormone is synthesized and secreted in the pineal gland. The suprachiasmatic nuclei in the hypothalamus maintains the circadian rhythms in the body including rest and activity from photic input. Synthesis and secretion of melatonin is activated by darkness and decreased via light. During jet lag or circadian rhythm disorders endogenous melatonin is not secreted. Administering exogenous melatonin helps to reset behavioral sleep patterns. It may also facilitate sleep.
Common side effects include:
Theanine2
Magnesium (with increased magnesium levels)5
Melatonin8
Contraindications2,5,8
Precautions2,5,8
Theanine
Magnesium
Melatonin
Store in a cool, dry place between 20–25°C (68–77°F). Keep away from moisture, heat, and direct sunlight. Keep out of reach of children. Follow any additional storage guidelines on the manufacturer’s label.
This information is for educational purposes only. This compounded product has not been reviewed, approved, or evaluated by the Food and Drug Administration for safety and effectiveness. This product is not intended to diagnose, treat, cure, or prevent any disease. No claims are made regarding treatment, cure, or prevention of any disease or condition.
This information may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.
