(Clinical Strength)
Available Dosage Strengths
0.055% / 0.5%
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GHK-Cu Description:1
GHK-Cu is a naturally occurring copper-binding peptide that plays a role in tissue remodeling and repair. It is composed of a tripeptide (glycine–histidine–lysine) complexed with copper (II). Endogenously present in human plasma, its levels decline with age.
Topical formulations of GHK-Cu are being used for their potential to support skin regeneration, improve skin appearance, and promote scalp health. There is some evidence that the peptide may also influence hair follicle growth.
Hyaluronic Acid Description2,3
Hyaluronic Acid, a glycosaminoglycan, has an important role for the skin. It helps maintain hydration, elasticity, and skin integrity. It also has a role in wound healing. As people age, the production of hyaluronic acid decreases, leading to drier and less elastic skin.
GHK-Cu1
The activity of GHK-Cu is thought to be multifaceted and includes:
GHK-Cu has been associated with the upregulation of genes involved in tissue repair, anti-inflammatory signaling, and antioxidant defense, and the downregulation of genes linked to fibrosis and oxidative stress.1
Evidence suggests GHK-Cu may enhance dermal fibroblast function, collagen synthesis, and extracellular matrix remodeling—factors that contribute to skin firmness, elasticity, and texture.1
GHK-Cu may modulate the follicular microenvironment through support of cell proliferation and anti-inflammatory effects. Preclinical studies have proposed its influence on hair follicle cycling and dermal papilla cell activity.1
Hyaluronic Acid2,3
Hyaluronic acid may have the following two mechanisms for its activity on the skin: 1) as a passive structural molecule and 2) as a signaling molecule (based on its molecular size). Hyaluronic acid has hydgroscopicity and viscoelasticity properties. It is highly anionic that can attract water. This attraction of water provides the ability of the skin to create volume and provide structural support. The signaling mechanism may be facilitated by its anti-inflammatory properties through its effects on cell migration and cell division.
GHK-Cu1
Common
Mild local irritation
Hyaluronic Acid
Common4
Contraindications: 1-4
Precautions: 1-4
Store at 2°C–8°C (36°F–46°F). Protect from light, heat, and moisture.
This information is for educational purposes only. This compounded product has not been reviewed, approved, or evaluated by the Food and Drug Administration for safety and effectiveness. This product is not intended to diagnose, treat, cure, or prevent any disease. No claims are made regarding treatment, cure, or prevention of any disease or condition.
This information may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.
