Available Dosage Strengths
0.3% / 0.5%
Want to Prescribe?
Estriol Description 1-5
Micronized estriol is a bioidentical form of estriol (E3)—one of the three naturally occurring estrogens in women (alongside estradiol and estrone). Estriol is the weakest estrogen, with a much lower receptor binding affinity and duration of action than estradiol (E2). Though the weakest estrogen, estriol shows potential for skin-rejuvenating properties such as restoring dermal thickness and elasticity. Estriol is most commonly used along with estradiol in postmenopausal women with estrogen-deficiency. Estriol can be combined with other compounds into a gel.
Hyaluronic Acid Description6,7
Hyaluronic Acid, a glycosaminoglycan, has an important role for the skin. It helps maintain hydration, elasticity, and skin integrity. It also has a role in wound healing. As people age, the production of hyaluronic acid decreases, leading to drier and less elastic skin.
Estriol1-5
Estriol acts by binding to estrogen receptors alpha (ERα) and beta (ERβ) in estrogen-responsive tissues, particularly the vaginal epithelium, bladder, urethra, and pelvic floor musculature.
Mechanisms and Effects:
Hyaluronic Acid6,7
Hyaluronic acid may have the following two mechanisms for its activity on the skin: 1) as a passive structural molecule and 2) as a signaling molecule (based on its molecular size). Hyaluronic acid has hydgroscopicity and viscoelasticity properties. It is highly anionic that can attract water. This attraction of water provides the ability of the skin to create volume and provide structural support. The signaling mechanism may be facilitated by its anti-inflammatory properties through its effects on cell migration and cell division.
Estrogen1-5
Common
Systemic (estriol) (rare at low doses):
Hyaluronic Acid
Common8
Contraindications: 1-5,8
Precautions: 1-5,8
Use caution in:
Store at 20°C to 25°C (68°F to 77°F) in a dry place, away from heat and light. Keep out of reach of children.
This information is for educational purposes only. This compounded product has not been reviewed, approved, or evaluated by the Food and Drug Administration for safety and effectiveness. This product is not intended to diagnose, treat, cure, or prevent any disease. No claims are made regarding treatment, cure, or prevention of any disease or condition.
This information may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.
