Estriol Cream

Available Dosage Strengths

1 mg/gm | 2 mg/gm

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Disclaimer: Images are for reference only; actual products may vary.

Product Overview

Description

Micronized estriol is a bioidentical form of estriol (E3)—one of the three naturally occurring estrogens in women (alongside estradiol and estrone). Estriol is the weakest estrogen, with a much lower receptor binding affinity and duration of action than estradiol (E2). Though the weakest estrogen, estriol shows potential for skin-rejuvenating properties such as restoring dermal thickness and elasticity. Estriol is most commonly used along with estradiol in postmenopausal women with estrogen-deficiency. Estriol is most commonly prepared in a transdermal cream, allowing for incremental dosing adjustments.^1-5

Mechanism of Action

Estriol acts by binding to estrogen receptors alpha (ERα) and beta (ERβ) in estrogen-responsive tissues, particularly the vaginal epithelium, bladder, urethra, and pelvic floor musculature.

Mechanisms and Effects:^1-5

Can help restore vaginal epithelial thickness and improves cell maturation index
Can improve blood flow, elasticity, and lubrication of vaginal tissues
Locally can improve thickening of dermal-epidermal junction, potentially improving skin firmness
May exert cytoprotective and anti-inflammatory effects on urogenital tissues

Adverse Reactions

Common: ^1-5

Transient burning, itching, or discharge
Spotting or light bleeding (usually resolves quickly)
Increased vaginal secretions

Systemic (rare at low doses):^1-5

Breast tenderness
Headache
Nausea
Edema

Contraindications & Precautions

Contraindications:^1-5

Active or history of estrogen-dependent cancers (e.g., breast, endometrial) — unless use is explicitly approved by an oncology or menopause specialist
Active or recent thromboembolic disease
Undiagnosed abnormal genital bleeding
Severe liver dysfunction
Hypersensitivity to estriol or excipients

Precautions:^1-5

Use caution in:

Women with a history of estrogen-sensitive malignancy
Liver disease
Migraines with aura
Uncontrolled hypertension

Storage

Store in a cool, dry place, away from direct light and heat; Room temperature (20°C–25°C / 68°F–77°F) is ideal. Keep out of reach of children and pets.

References

1. Cynthia A. Stuenkel, Susan R. Davis, Anne Gompel, Mary Ann Lumsden, M. Hassan Murad, JoAnn V. Pinkerton, Richard J. Santen, Treatment of Symptoms of the Menopause: An Endocrine Society Clinical Practice Guideline, The Journal of Clinical Endocrinology & Metabolism, Volume 100, Issue 11, 1 November 2015, Pages 3975–4011, accessed July 2025 through: https://doi.org/10.1210/jc.2015-2236

2.North American Menopause Society (NAMS) Position Statement on Hormone Therapy (2022) Supports vaginal estrogen (including estriol) for GSM with minimal systemic risks; accessed July 2025 through: https://www.menopause.org/docs/default-source/professional/2022-nams-ht-position-statement.pdf

3. NIH DailyMed, Estriol; accessed July 2025 though: https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=estriol

4. Estriol: A Comprehensive Guide for Patients; accessed July 2025 through: https://clinicaltrials.eu/inn/estriol/

5. Rzepecki AK, Murase JE, Juran R, Fabi SG, McLellan BN. Estrogen-deficient skin: The role of topical therapy. Int J Womens Dermatol. 2019 Mar 15;5(2):85-90. Accessed July 2025; doi: 10.1016/j.ijwd.2019.01.001. PMID: 30997378; PMCID: PMC6451761

Disclaimer

This information is for educational purposes only. This compounded product has not been reviewed, approved, or evaluated by the Food and Drug Administration for safety and effectiveness. This product is not intended to diagnose, treat, cure, or prevent any disease. No claims are made regarding treatment, cure, or prevention of any disease or condition.

This information may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.