Available Dosage Strengths
0.3% / 1% / 0.05% / 6.5% / 0.01%
Want to Prescribe?
This potent topical formulation for men combines dutasteride, hydrocortisone, latanoprost, minoxidil, and tretinoin to target hair loss through dihydrotestosterone suppression, follicle stimulation, inflammation control, and enhanced absorption of active ingredients. Each drug has a unique mechanism of action to support development and growth of hair. Designed for androgenetic alopecia, it supports hair regrowth, scalp health, and improved hair density.
Dutasteride Description1-3
Dutasteride, a 5-alpha inhibitor, is a 4-azo analog of testosterone. It also has been found to be efficacious for androgenic alopecia, also known as male pattern hair loss.
Hydrocortisone4,5
Hydrocortisone, a steroid hormone that systematically has both glucocorticoid and mineralocorticoid activity, is the synthetic form of cortisol. Cortisol is a hormone produced by the adrenal glands. Hydrocortisone topically has anti-inflammatory, antipruritic, anti-mitotic, and immunosuppressive properties. There are many topical steroids available on the market. Hydrocortisone is a low potency steroid.
Latanoprost6-10
Latanoprost works by mimicking prostaglandin F2α (PGF2α) to minimize glaucoma and to stimulate hair growth. There is evidence that the drug promotes hair growth, particularly in androgenetic alopecia (AGA) and eyelash/eyebrow hypotrichosis.6-8 Its role in hair regrowth was first noted due to its adverse effect of increased eyelash growth in glaucoma patients.
Minoxidil11-13
Topical minoxidil is a vasodilatory compound originally developed as an oral antihypertensive agent. It was found to stimulate hair growth (from the observation of hypertrichosis (excessive, abnormal hair growth) in patients taking oral minoxidil) and was subsequently FDA approved for androgenetic alopecia (male and female pattern hair loss).
Tretinoin14-18
Tretinoin, a naturally occurring derivative of vitamin A, is also called all-trans-retinoic acid. Retinoids may facilitate regulation of cell reproduction, cell proliferation and differentiation. Combing tretinoin and minoxidil may provide a synergistic increase in the expression of hair growth markers (e.g., Erk, Akt, Bcl-2, and Bax).
Dutasteride1-3
Dutasteride is a 4-azo analog of testosterone. It competitively and selectively inhibits both reproductive tissues (type 2) and skin and hepatic (type 1) 5α-reductase. This activity of dutasteride prevents the conversion of testosterone to dihydrotestosterone and significantly suppresses serum dihydrotestosterone levels. The type II 5-alpha-reductase isozyme is primarily found in prostate, seminal vesicles, epididymides, and hair follicles, as well as liver. Dihydrotestosterone has been shown to increase prostate growth and can lead to hair thinning.
Hydrocortisone4,5
The anti-inflammatory effects of topical hydrocortisone may occur through vasoconstriction. The vasoconstriction minimizes inflammatory mediators delivered to the inflamed area. Topical hydrocortisone may also inhibit the release of phospholipase A2, which reduces prostaglandins and leukotriene. Lastly, topical hydrocortisone inhibits DNA and transcription factors related to inflammation. It does this by increasing the expression of anti-inflammatory genes and indirectly inhibit inflammatory transcription factors, such as NF-kB, to decrease the expression of pro-inflammatory genes.
Topical hydrocortisone also has an anti-mitotic effect by decreasing epidermal mitosis mediated through an increase in lipocortin, an endogenous glucocorticoid-regulated protein.
Topical hydrocortisone also inhibits humoral factors in the inflammatory response by suppressing immune cells from maturing, differentiating and proliferating.
Latanoprost6-10
Latanoprost binds to the prostaglandin F2α receptor on hair follicle dermal papilla cells, influencing the hair growth cycle as follows:
Increases the duration of anagen, which may result in longer and thicker hair shafts.
May enhance pigmentation in vellus hairs, which may make them appear darker and more terminal-like.
Some studies suggest latanoprost may increase the number of follicles actively producing hair, particularly in the eyelash and eyebrow regions, and potentially the scalp.
Minoxidil11-13
The drug has many mechanisms in supporting hair growth:
Tretinoin14-17
Tretinoin may have several mechanisms to facilitate hair growth including the following:
Dutasteride1-3
Common
With systematic absorption (rare)
Hydrocortisone4
Common
Latanoprost9,10
Common
Minoxidil11-13
Common
Topical minoxidil is generally well tolerated but may cause local effects:
Tretinoin14
Common
Contraindications 1-4,9,10-14
Precautions 1-4,9,10-14
Store at room temperatures between (59-86°F). Protect from light and keep the container tightly closed. Women should not handle crushed or broken finasteride tablets when they are pregnant or may potentially be pregnant because of the possibility of absorption of finasteride and the subsequent potential risk to a male fetus. Keep out of reach of children and pets.
This information is for educational purposes only. This compounded product has not been reviewed, approved, or evaluated by the Food and Drug Administration for safety and effectiveness. This product is not intended to diagnose, treat, cure, or prevent any disease. No claims are made regarding treatment, cure, or prevention of any disease or condition.
This information may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.
