Available Dosage Strengths
15% / 0.3%
Want to Prescribe?
Ascorbic Acid_Estriol Cream is a compounded topical product used to decrease skin aging including fine lines, dullness, dryness, and loss of elasticity. Ascorbic Acid is an antioxidant and may provide collagen-supporting benefits. Estriol can support skin hydration and structural integrity.
Ascorbic Acid1-5
Ascorbic acid (vitamin C) an antioxidant and a water-soluble vitamin is a critical co-factor for collagen biosynthesis, carnitine and catecholamine metabolism, and systemically dietary iron absorption. Ascorbic acid is an important component to ensure that skin has a healthy integrity. Along with its antioxidant properties for the skin, it has anti-inflammatory activity, acts as a depigmenting agent, and helps in the development of collagen. Ascorbic acid deficiency causes skin aging. Thus, the external supplementation of ascorbic acid is one of the attractive strategies for skin antiaging
Ascorbic acid is not made in the body and needs to be obtained through diet or through supplements. Dietary sources of ascorbic acid include citrus fruits, berries, tomatoes, potatoes and green leafy vegetables.
Estriol6-10
Micronized estriol is a bioidentical form of estriol (E3)—one of the three naturally occurring estrogens in women (alongside estradiol and estrone). Estriol is the weakest estrogen, with a much lower receptor binding affinity and duration of action than estradiol (E2). Though the weakest estrogen, estriol shows potential for skin-rejuvenating properties such as restoring dermal thickness and elasticity. Estriol is most commonly used along with estradiol in postmenopausal women with estrogen-deficiency. Estriol is most commonly prepared in a transdermal cream, allowing for incremental dosing adjustments.
Ascorbic Acid1-5
Ascorbic acid functions in the aqueous compartments of the cell. As an antioxidant, ascorbic acid neutralizes free radicals by donating electrons to prevent oxidative stress. Reactive oxygen species are formed when skin is exposed to ultraviolet light forming superoxide ions, peroxide and singlet oxygen species. Ascorbic acid facilitates collagen development. It plays an important role in the maturation of collagen. It is a critical co-factor for prolyl hydroxylase and lysl hydroxylase. The level of ascorbic acid in the skin is directly tied to the structural integrity of dermal collagen. As a depigmenting agent, ascorbic acid interacts with copper ions at the tyrosinase‑active site and inhibits action of the enzyme tyrosinase, thereby minimizing the melanin formation. Ascorbic acid interferes with NFkB activity and thus decreases the activity of a number of pro‑inflammatory cytokines such as TNF‑alfa, IL1, IL6 and IL8.
Estriol6-10
Estriol acts by binding to estrogen receptors alpha (ERα) and beta (ERβ) in estrogen-responsive tissues, particularly the vaginal epithelium, bladder, urethra, and pelvic floor musculature.
Mechanisms and Effects:
– Can help restore vaginal epithelial thickness and improves cell maturation index
– Can improve blood flow, elasticity, and lubrication of vaginal tissues
– Locally can improve thickening of dermal-epidermal junction, potentially improving skin firmness
– May exert cytoprotective and anti-inflammatory effects on urogenital tissues
Common: 6-10
Systemic (rare at low doses): 6-10
Contraindications: 6-10
Precautions: 6-10
Use caution in:
Store at 20°C to 25°C (68°F to 77°F) in a dry place, away from heat and light. Keep out of reach of children.
This sheet is a summary. It may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.
